哇巴因对人及小鼠干扰素的抗细胞和抗病毒活性的影响。
Effects of ouabain on the anticellular and antiviral activities of human and mouse interferon.
作者信息
Kuwata T, Fuse A, Morinaga N
出版信息
J Gen Virol. 1977 Mar;34(3):537-40. doi: 10.1099/0022-1317-34-3-537.
PMID:192839
Abstract
When transformed human embryonic cells, RSa and RSb, were treated for 48 h with both 10(-7) M-ouabain and 1000 units/ml of human leucocyte inteferon, there was an additive suppression of cell growth. In contrast, the antiviral action of the human interferon was inhibited by this concentration of ouabain. Similar effects of combined treatment with interferon and ouabain were found with IFr cells (which are relatively resistant to the anticellular effect of interferon), and with mouse cells of the K3b line.
摘要
当将转化的人胚胎细胞RSa和RSb用10⁻⁷M哇巴因和1000单位/毫升人白细胞干扰素处理48小时时，细胞生长受到累加性抑制。相比之下，该浓度的哇巴因会抑制人干扰素的抗病毒作用。在IFr细胞（对干扰素的抗细胞作用相对耐药）和K3b系小鼠细胞中也发现了干扰素与哇巴因联合处理的类似效果。
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