霍乱毒素对人白细胞干扰素抗病毒和抗细胞活性的影响。
Effect of cholera toxin on the antiviral and anticellular activities of human leukocyte interferon.
作者信息
Fuse A, Kuwata T
出版信息
Infect Immun. 1979 Oct;26(1):235-9. doi: 10.1128/iai.26.1.235-239.1979.
Abstract
Cholera toxin added into cell cultures together with human leukocyte interferon inhibited the establishment of the antiviral state by interferon but not the anticellular activity of interferon in human cells. Sensitivities of various human cell lines to anticellular activities of interferon and cholera toxin were compared, but no direct correlation between both activities were demonstrated. These results suggest that antiviral and anticellular activities of interferon are due to different mechanism of actions, and cholera toxin does not act directly on the receptor site for interferon.
摘要
将霍乱毒素与人白细胞干扰素一同添加到细胞培养物中，可抑制干扰素建立抗病毒状态，但不会抑制干扰素在人体细胞中的抗细胞活性。比较了各种人类细胞系对干扰素和霍乱毒素抗细胞活性的敏感性，但未证明两者活性之间存在直接相关性。这些结果表明，干扰素的抗病毒和抗细胞活性是由不同的作用机制引起的，并且霍乱毒素不会直接作用于干扰素的受体位点。
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本文引用的文献
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Infect Immun. 1971 Dec;4(6):747-52. doi: 10.1128/iai.4.6.747-752.1971.
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Cholera toxin and cell growth: role of membrane gangliosides.霍乱毒素与细胞生长：膜神经节苷脂的作用
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Binding of interferon to gangliosides.干扰素与神经节苷脂的结合。
Nature. 1974 Dec 6;252(5483):478-80. doi: 10.1038/252478a0.
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Specificity and reversibility of interferon ganglioside interaction.干扰素与神经节苷脂相互作用的特异性和可逆性。
Nature. 1976 Feb 19;259(5544):576-8. doi: 10.1038/259576a0.
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Separation of antiviral activity of human interferon from cell growth inhibitory effect.人干扰素抗病毒活性与细胞生长抑制作用的分离。
Nature. 1975 Oct 30;257(5529):799-800. doi: 10.1038/257799a0.
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Non-antiviral activities of interferon are not controlled by chromosome 21.干扰素的非抗病毒活性不受21号染色体控制。
Nature. 1975 Jul 10;256(5513):132-4. doi: 10.1038/256132a0.
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