Ruediger Hugo W
Division of Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Berggasse 4/33, 1090 Vienna, Austria.
Pathophysiology. 2009 Aug;16(2-3):89-102. doi: 10.1016/j.pathophys.2008.11.004. Epub 2009 Mar 13.
101 publications are exploited which have studied genotoxicity of radiofrequency electromagnetic fields (RF-EMF) in vivo and in vitro. Of these 49 report a genotoxic effect and 42 do not. In addition, 8 studies failed to detect an influence on the genetic material, but showed that RF-EMF enhanced the genotoxic action of other chemical or physical agents. The controversial results may in part be explained by the different cellular systems. Moreover, inconsistencies may depend from the variety of analytical methods being used, which differ considerably with respect to sensitivity and specificity. Taking altogether there is ample evidence that RF-EMF can alter the genetic material of exposed cells in vivo and in vitro and in more than one way. This genotoxic action may be mediated by microthermal effects in cellular structures, formation of free radicals, or an interaction with DNA-repair mechanisms.
我们利用了101篇研究射频电磁场（RF-EMF）体内和体外遗传毒性的出版物。其中49篇报告了遗传毒性效应，42篇未报告。此外，8项研究未能检测到对遗传物质的影响，但表明RF-EMF增强了其他化学或物理剂的遗传毒性作用。这些有争议的结果部分可能是由不同的细胞系统所解释的。此外，不一致性可能取决于所使用的各种分析方法，这些方法在灵敏度和特异性方面有很大差异。总体而言，有充分证据表明RF-EMF可以在体内和体外以多种方式改变暴露细胞的遗传物质。这种遗传毒性作用可能由细胞结构中的微热效应、自由基的形成或与DNA修复机制的相互作用介导。
