Langer K, Rappersberger K, Steiner A, Konrad K, Wolff K
Department of Dermatology I, University of Vienna Medical School, Austria.
Arch Dermatol Res. 1990;282(6):353-62. doi: 10.1007/BF00372084.
Eleven dysplastic melanocytic naevi with various degrees of dysplasia, as judged by light microscopy, were studied by transmission electron microscopy, and their intra-epidermal melanocytes compared with those of five superficial spreading melanomas and seven common benign naevocellular naevi. Intra-epidermal melanocytes in dysplastic naevi exhibited signs of cellular atypia, which were most pronounced in the dysplastic naevi with histological high-grade dysplasia. A correlation between the degree of dysplasia at the light microscopic level and the degree of cytological atypia at the ultrastructural level was noted, and melanocytes in dysplastic naevi with a high degree of dysplasia had ultrastructural features similar to the melanocytes in superficial spreading melanomas. Our observations support the concept that dysplastic naevi fill the biological gap between benign naevocellular naevi and malignant melanomas and suggest that at least some of the dysplastic naevi must be regarded as potential precursor lesions of malignant melanoma, particularly those exhibiting a high degree of histological dysplasia.
通过光学显微镜判断，选取了11个具有不同程度发育异常的发育异常性黑素细胞痣，采用透射电子显微镜进行研究，并将其表皮内黑素细胞与5个浅表扩散性黑色素瘤及7个常见的良性痣细胞痣的表皮内黑素细胞进行比较。发育异常性痣的表皮内黑素细胞表现出细胞异型性的迹象，在组织学上具有高级别发育异常的发育异常性痣中最为明显。在光学显微镜水平上的发育异常程度与超微结构水平上的细胞学异型性程度之间存在相关性，具有高度发育异常的发育异常性痣中的黑素细胞具有与浅表扩散性黑色素瘤中的黑素细胞相似的超微结构特征。我们的观察结果支持这样的概念，即发育异常性痣填补了良性痣细胞痣与恶性黑色素瘤之间的生物学空白，并表明至少一些发育异常性痣必须被视为恶性黑色素瘤的潜在前驱病变，特别是那些表现出高度组织学发育异常的病变。
