Tsegay Filmon, Elsherif Mohamed, Butt Haider
Department of Mechanical Engineering, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.
Polymers (Basel). 2022 Mar 3;14(5):1012. doi: 10.3390/polym14051012.
Wounds are a major health concern affecting the lives of millions of people. Some wounds may pass a threshold diameter to become unrecoverable by themselves. These wounds become chronic and may even lead to mortality. Recently, 3D printing technology, in association with biocompatible hydrogels, has emerged as a promising platform for developing smart wound dressings, overcoming several challenges. 3D printed wound dressings can be loaded with a variety of items, such as antibiotics, antibacterial nanoparticles, and other drugs that can accelerate wound healing rate. 3D printing is computerized, allowing each level of the printed part to be fully controlled in situ to produce the dressings desired. In this review, recent developments in hydrogel-based wound dressings made using 3D printing are covered. The most common biosensors integrated with 3D printed hydrogels for wound dressing applications are comprehensively discussed. Fundamental challenges for 3D printing and future prospects are highlighted. Additionally, some related nanomaterial-based hydrogels are recommended for future consideration.
伤口是一个重大的健康问题，影响着数百万人的生活。一些伤口可能会超过某个临界直径，从而无法自行愈合。这些伤口会变成慢性伤口，甚至可能导致死亡。最近，3D打印技术与生物相容性水凝胶相结合，已成为开发智能伤口敷料的一个有前景的平台，克服了若干挑战。3D打印的伤口敷料可以加载各种物品，如抗生素、抗菌纳米颗粒和其他能够加速伤口愈合速度的药物。3D打印是计算机化的，能够对打印部件的每个层面进行原位全面控制，以生产出所需的敷料。在这篇综述中，涵盖了使用3D打印制作的基于水凝胶的伤口敷料的最新进展。全面讨论了用于伤口敷料应用的与3D打印水凝胶集成的最常见生物传感器。突出了3D打印的基本挑战和未来前景。此外，还推荐了一些相关的基于纳米材料的水凝胶以供未来考虑。
