Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Int J Nanomedicine. 2022 Jul 20;17:3125-3145. doi: 10.2147/IJN.S372211. eCollection 2022.
Wounds occur when skin integrity is broken and the skin is damaged. With progressive changes in the disease spectrum, the acute wounds caused by mechanical trauma have been become less common, while chronic wounds triggered with aging, diabetes and infection have become more frequent. Chronic wounds now affect more than 6 million people in the United States, amounting to 10 billion dollars in annual expenditure. However, the treatment of chronic wounds is associated with numerous challenges. Traditional remedies for chronic wounds include skin grafting, flap transplantation, negative-pressure wound therapy, and gauze dressing, all of which can cause tissue damage or activity limitations. Nanobiotechnology - which comprises a diverse array of technologies derived from engineering, chemistry, and biology - is now being applied in biomedical practice. Here, we review the design, application, and clinical trials for nanotechnology-based therapies for chronic wound healing, highlighting the clinical potential of nanobiotechnology in such treatments. By summarizing previous nanobiotechnology studies, we lay the foundation for future wound care via a nanotech-based multifunctional smart system.
当皮肤完整性被破坏且皮肤受损时，就会出现伤口。随着疾病谱的不断变化，由机械创伤引起的急性伤口已变得较为少见，而由衰老、糖尿病和感染引发的慢性伤口则更为常见。目前，慢性伤口在美国影响着超过 600 万人，每年的花费高达 100 亿美元。然而，慢性伤口的治疗存在诸多挑战。慢性伤口的传统治疗方法包括植皮、皮瓣移植、负压伤口治疗和纱布敷料，这些方法都会造成组织损伤或活动受限。纳米生物技术——涵盖了工程学、化学和生物学等多个领域的技术——现已应用于生物医学实践中。在此，我们综述了基于纳米技术的慢性伤口愈合治疗方法的设计、应用和临床试验，重点介绍了纳米生物技术在这些治疗中的临床应用潜力。通过总结之前的纳米生物技术研究，我们为基于纳米技术的多功能智能系统的未来伤口护理奠定了基础。
