Keller Simon Sean, Baker Gus, Downes Joseph John, Roberts Neil
Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Pembroke Place, Liverpool L69 3BX, UK.
Epilepsy Behav. 2009 Jun;15(2):186-95. doi: 10.1016/j.yebeh.2009.03.005. Epub 2009 Apr 11.
We investigated the relationship between prefrontal cortex (PFC) and hippocampal volume and executive functioning in patients with temporal lobe epilepsy (TLE). Prefrontal volume and hippocampal volume were studied using stereology in conjunction with point counting and voxel-based morphometry on MR images. Executive functioning was assessed using tests routinely incorporated into presurgical neuropsychological evaluation. Relative to 30 healthy controls, 43 patients (26 left, 17 right) with TLE had volume atrophy of the ipsilateral hippocampus and bilateral dorsal PFC. Performance on the working memory index of the Wechsler Memory Scale was positively correlated with the volume of all prefrontal regions, and the Controlled Oral Word Association Test with the left dorsal PFC, whole left PFC, and left hippocampus. Stroop Color-Word Interference performance was not related to volume of dorsal PFC. The "extratemporal neuropsychological profile" frequently observed in patients with TLE may be due to extended damage to brain regions remote from the epileptogenic focus. In particular, volume atrophy of the dorsal PFC may account for deficits in executive functioning.
我们研究了颞叶癫痫（TLE）患者前额叶皮质（PFC）与海马体体积及执行功能之间的关系。在磁共振成像上，采用体视学结合点计数法和基于体素的形态测量法研究前额叶体积和海马体体积。使用术前神经心理学评估中常规纳入的测试评估执行功能。相对于30名健康对照者，43例TLE患者（26例左侧，17例右侧）同侧海马体和双侧背侧PFC存在体积萎缩。韦氏记忆量表工作记忆指数的表现与所有前额叶区域的体积呈正相关，而受控口语词语联想测验的表现与左侧背侧PFC、整个左侧PFC和左侧海马体的体积呈正相关。Stroop颜色-词语干扰任务的表现与背侧PFC的体积无关。TLE患者中经常观察到的“颞外神经心理学特征”可能是由于远离致痫灶的脑区受到广泛损害所致。特别是，背侧PFC的体积萎缩可能导致执行功能缺陷。
