Richlan Fabio, Kronbichler Martin, Wimmer Heinz
Department of Psychology and Center for Neurocognitive Research, University of Salzburg, Salzburg, Austria.
Hum Brain Mapp. 2009 Oct;30(10):3299-308. doi: 10.1002/hbm.20752.
This study used foci from 17 original studies on functional abnormalities in the dyslexic brain to identify brain regions with consistent under- or overactivation. Studies were included when reading or reading-related tasks were performed on visually presented stimuli and when results reported coordinates for group differences. Activation likelihood estimation (ALE) was used for quantification. Maxima of underactivation were found in inferior parietal, superior temporal, middle and inferior temporal, and fusiform regions of the left hemisphere. With respect to left frontal abnormalities, we found underactivation in the inferior frontal gyrus to be accompanied by overactivation in the primary motor cortex and the anterior insula. Tentative functional interpretations of the activation abnormalities are provided.
本研究使用了来自17项关于诵读困难大脑功能异常的原始研究中的病灶，以确定激活不足或过度激活一致的脑区。当对视觉呈现的刺激执行阅读或阅读相关任务，且研究报告了组间差异的坐标时，这些研究被纳入。采用激活可能性估计（ALE）进行量化。在左半球的顶下、颞上、颞中、颞下和梭状回区域发现了激活不足的最大值。关于左额叶异常，我们发现额下回激活不足，同时初级运动皮层和前岛叶过度激活。本文提供了对激活异常的初步功能解释。
