Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 807.
Depress Anxiety. 2009;26(11):1033-9. doi: 10.1002/da.20413.
The aims of this study were to examine whether different domains of quality of life (QOL) are differently affected by depressive disorders by comparing QOL of subjects with and without depressive disorders, and to examine the association of QOL with self-stigma, insight and adverse effects of medication among subjects with depressive disorders.
The QOL on the four domains of the WHOQOL-BREF Taiwan version were compared between the 229 subjects with depressive disorders and 106 control subjects. Among the depressive subjects, the association between the four QOL domains and subjects' self-stigma, insight, and adverse effects of medication were examined using multiple regression analyses by controlling for the influence of depression, socio-demographic and clinical characteristics and family function.
Depressive subjects had poorer QOL on the physical, psychological and social relationship domains than the non-depressive control group. The depressive subjects who had more severe self-stigma had poorer QOL on all four domains. The depressive subjects who perceived more severe adverse effects from medication had poorer QOL on the physical, psychological and environmental domains. However, insight was not associated with any domain of QOL in patients with depressive disorders.
The results of this study demonstrate that different domains of QOL are differently affected by depressive disorders, and that clinicians must consider the negative influences of self-stigma and adverse effects from medication on QOL of subjects with depressive disorders.
本研究旨在通过比较有和无抑郁障碍受试者的生活质量（QOL），来探讨不同领域的 QOL 是否受抑郁障碍的影响不同，并检验 QOL 与抑郁障碍受试者的自我污名、洞察力和药物不良反应之间的相关性。
将 WHOQOL-BREF 台湾版的四个领域的 QOL 在 229 名抑郁障碍受试者和 106 名对照组受试者之间进行比较。在抑郁障碍受试者中，通过控制抑郁、社会人口学和临床特征以及家庭功能的影响，使用多元回归分析检验四个 QOL 领域与受试者自我污名、洞察力和药物不良反应之间的关系。
与非抑郁对照组相比，抑郁障碍受试者在身体、心理和社会关系领域的 QOL 较差。自我污名程度越严重的抑郁障碍受试者，所有四个领域的 QOL 越差。感知药物不良反应越严重的抑郁障碍受试者，身体、心理和环境领域的 QOL 越差。然而，洞察力与抑郁障碍患者的任何 QOL 领域均无相关性。
本研究结果表明，不同领域的 QOL 受抑郁障碍的影响不同，临床医生必须考虑自我污名和药物不良反应对抑郁障碍患者 QOL 的负面影响。
