糖尿病肥胖症中内源性大麻素系统的失调——一个棘手的问题。
The dysregulation of the endocannabinoid system in diabesity-a tricky problem.
作者信息
Scherer Thomas, Buettner Christoph
机构信息
Department of Medicine and Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1055, New York, NY 10029-6574, USA.
出版信息
J Mol Med (Berl). 2009 Jul;87(7):663-8. doi: 10.1007/s00109-009-0459-y. Epub 2009 Mar 17.
Abstract
Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy metabolism. Human studies have shown that the EC tone in peripheral tissues positively correlates with increased adiposity. Furthermore, pharmacological inhibition of EC signaling results in weight loss in humans. However, the mechanisms that cause the dysregulation of the EC system in obesity are not well-understood. Since the clinical utility of currently available EC blockers is severely limited due to their side effects like depression and suicidal ideation that are caused by central effects, it is important to delineate the role of central and peripheral effects of EC signaling in regulating glucose and lipid metabolism.
摘要
内源性大麻素（ECs）是一类小的脂质介质，在能量代谢中起关键作用。人体研究表明，外周组织中的EC水平与肥胖程度增加呈正相关。此外，对EC信号通路的药理学抑制可导致人体体重减轻。然而，肥胖中导致EC系统失调的机制尚未完全明确。由于目前可用的EC阻滞剂存在诸如由中枢效应引起的抑郁和自杀念头等副作用，其临床应用受到严重限制，因此明确EC信号通路的中枢和外周效应在调节葡萄糖和脂质代谢中的作用非常重要。
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2
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Diabetologia. 2009 Feb;52(2):213-7. doi: 10.1007/s00125-008-1178-6.
3
Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.
Diabetes. 2008 Nov;57(11):2977-91. doi: 10.2337/db08-0161. Epub 2008 Aug 20.
4
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
J Clin Invest. 2008 Sep;118(9):3160-9. doi: 10.1172/JCI34827.
5
The CB1 endocannabinoid system modulates adipocyte insulin sensitivity.
Obesity (Silver Spring). 2008 Aug;16(8):1727-34. doi: 10.1038/oby.2008.309. Epub 2008 Jun 12.
6
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Nat Med. 2008 Jun;14(6):667-75. doi: 10.1038/nm1775. Epub 2008 Jun 1.
7
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J Neuroendocrinol. 2008 May;20 Suppl 1:130-8. doi: 10.1111/j.1365-2826.2008.01682.x.
8
Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets.
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9
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