Stefanidou M, Athanaselis S, Spiliopoulou H
Department of Forensic Medicine and Toxicology, Medical School, University of Athens, 75 M. Asias Street, Goudi 115.27, Greece.
Intern Med J. 2009 Jan;39(1):57-60. doi: 10.1111/j.1445-5994.2008.01779.x.
Butyrylcholinesterase (BuChE) is routinely measured to assess exposure to or effects of organophosphorus insecticides (OP). As a biomarker, it can be used to clarify the relation between exposure to OP and health impairment. The interpretation of BuChE inhibition data, particularly of small changes in enzymatic activity, sometimes presents significant complexities. These complexities are presented in this short communication and the factors that influence the degree of BuChE inhibition are discussed. Despite the complexities of their interpretation, BuChE measurements remain a mainstay for the fast initial screening of exposure to OP; thus, they are a useful tool in the protection of humans, domestic animals and wildlife from overexposure to these toxic agents.
通常会检测丁酰胆碱酯酶（BuChE）以评估有机磷杀虫剂（OP）的接触情况或其影响。作为一种生物标志物，它可用于阐明OP接触与健康损害之间的关系。对BuChE抑制数据的解读，尤其是酶活性的微小变化，有时会呈现出显著的复杂性。本简短通讯阐述了这些复杂性，并讨论了影响BuChE抑制程度的因素。尽管解读存在复杂性，但BuChE检测仍是OP接触快速初步筛查的主要手段；因此，它是保护人类、家畜和野生动物免受这些有毒物质过度暴露的有用工具。
