Yang C M, Lin M F, Liao P C, Yeh H W, Chang B V, Tang T K, Cheng C, Sung C H, Liou M L
Department of Health, Hsin-Chu General Hospital, Hsin-Chu, Taiwan.
Lett Appl Microbiol. 2009 May;48(5):560-5. doi: 10.1111/j.1472-765X.2009.02572.x. Epub 2009 Mar 9.
To compare bacterial populations and antimicrobial resistance patterns between clinical and sewage isolates from a regional hospital in northern Taiwan. The dissemination of antibiotic-resistant bacteria from hospital compartments to the hospital sewage treatment plant was examined.
A total of 1020 clinical isolates and 435 sewage isolates were collected between July and September 2005. The percentages of Gram-negative bacteria from the clinical and sewage isolates were 87.2% and 91.0%, respectively (P = 0.033). Escherichia coli were the leading bacterial isolates in both groups. Antimicrobial susceptibility testing showed a significant difference (P < 0.001) in resistance to ampicillin (85.6% vs 94.1%), ampicillin/sulbactam (31.7% vs 55.4%), cefazolin (29.2% vs 71.5%) and cefuroxime (20.7% vs 61.9%) between clinical and sewage coliform isolates, respectively.
The sewage isolates had higher antimicrobial resistance rates than the clinical isolates from the same hospital.
The low efficacy of the hospital sewage treatment may contribute to the dissemination of multidrug resistant bacteria from this hospital compartments to the environment. Practices which limit the disposal of antimicrobial agents into the wastewater system may be the possible measure to prevent the selection of multidrug-resistant bacteria from sewage treatment plants.
比较台湾北部一家地区医院临床分离株和污水分离株之间的细菌种群及抗菌药物耐药模式。研究医院不同区域的抗生素耐药菌向医院污水处理厂的传播情况。
2005年7月至9月期间共收集了1020株临床分离株和435株污水分离株。临床分离株和污水分离株中革兰氏阴性菌的比例分别为87.2%和91.0%（P = 0.033）。两组中大肠埃希菌都是主要的细菌分离株。抗菌药物敏感性试验显示，临床和污水大肠菌群分离株对氨苄西林（85.6%对94.1%）、氨苄西林/舒巴坦（31.7%对55.4%）、头孢唑林（29.2%对71.5%）和头孢呋辛（20.7%对61.9%）的耐药性存在显著差异（P < 0.001）。
污水分离株的抗菌药物耐药率高于同一家医院的临床分离株。
医院污水处理效果不佳可能导致该医院不同区域的多重耐药菌向环境传播。限制抗菌药物排入废水系统的做法可能是防止污水处理厂产生多重耐药菌的一项可行措施。
Zotero 插件