Ausborn Jessica, Wolf Harald, Stein Wolfgang
Department of Neuroscience, Karolinska Institute, Stockholm, 17177, Sweden.
J Comput Neurosci. 2009 Oct;27(2):245-57. doi: 10.1007/s10827-009-0140-z. Epub 2009 Mar 17.
In many rhythmic behaviors, phasic sensory feedback modifies the motor pattern. This modification is assumed to depend on feedback sign (positive vs. negative). While on a phenomenological level feedback sign is well defined, many sensory pathways also process antagonistic, and possibly contradictory, sensory information. We here model the locust flight pattern generator and proprioceptive feedback provided by the tegula wing receptor to test the functional significance of sensory pathways processing antagonistic information. We demonstrate that the tegula provides delayed positive feedback via interneuron 301, while all other pathways provide negative feedback. Contradictory to previous assumptions, the increase of wing beat frequency when the tegula is activated during flight is due to the positive feedback. By use of an abstract model we reveal that the regulation of motor pattern frequency by sensory feedback critically depends on the interaction of positive and negative feedback, and thus on the weighting of antagonistic pathways.
在许多节律性行为中，相位性感觉反馈会改变运动模式。这种改变被认为取决于反馈信号（正反馈与负反馈）。虽然在现象学层面上反馈信号定义明确，但许多感觉通路也会处理对抗性的、甚至可能相互矛盾的感觉信息。我们在此对蝗虫飞行模式发生器以及 tegula 翅感受器提供的本体感受反馈进行建模，以测试处理对抗性信息的感觉通路的功能意义。我们证明，tegula 通过中间神经元 301 提供延迟的正反馈，而所有其他通路提供负反馈。与之前的假设相反，飞行过程中激活 tegula 时翅膀拍击频率的增加是由于正反馈。通过使用一个抽象模型，我们揭示感觉反馈对运动模式频率的调节关键取决于正反馈和负反馈的相互作用，因此取决于对抗性通路的权重。
