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静脉注射氧氟沙星意外过量，结局良好。

Accidental overdose of intravenous ofloxacin with benign outcome.

作者信息

Kohler R B, Arkins N, Tack K J

机构信息

Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.

出版信息

Antimicrob Agents Chemother. 1991 Jun;35(6):1239-40. doi: 10.1128/AAC.35.6.1239.

DOI:10.1128/AAC.35.6.1239
PMID:1929271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284320/
Abstract

A patient accidentally received approximately 3 g of ofloxacin intravenously. She experienced only moderately severe central nervous system symptoms, which resolved within 9 h. The peak serum ofloxacin level was 39.3 micrograms/ml, approximately seven times the usual peak level. Ofloxacin may possess a considerable safety margin in humans.

摘要

一名患者意外静脉注射了约3克氧氟沙星。她仅出现了中度严重的中枢神经系统症状，这些症状在9小时内得到缓解。血清中氧氟沙星的峰值水平为39.3微克/毫升，约为通常峰值水平的7倍。氧氟沙星在人体中可能具有相当大的安全范围。

相似文献

1
Accidental overdose of intravenous ofloxacin with benign outcome.静脉注射氧氟沙星意外过量，结局良好。
Antimicrob Agents Chemother. 1991 Jun;35(6):1239-40. doi: 10.1128/AAC.35.6.1239.
2
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引用本文的文献

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Ofloxacin. A reappraisal of its antimicrobial activity, pharmacology and therapeutic use.氧氟沙星。对其抗菌活性、药理学及治疗用途的重新评估。
Drugs. 1991 Nov;42(5):825-76. doi: 10.2165/00003495-199142050-00008.

本文引用的文献

1
Ciprofloxacin: an update on clinical experience.环丙沙星：临床经验最新进展
Am J Med. 1987 Apr 27;82(4A):381-6.
2
Norfloxacin and seizures.诺氟沙星与癫痫发作
Ann Intern Med. 1988 Jul 15;109(2):169-70. doi: 10.7326/0003-4819-109-2-169.
3
Side effects of ofloxacin in clinical trials and in postmarketing surveillance.氧氟沙星在临床试验及上市后监测中的副作用。 （注：原文中多了一个of，正确表述应该是Side effects of ofloxacin... ）
Drugs. 1987;34 Suppl 1:144-9. doi: 10.2165/00003495-198700341-00031.
4
Efficacy, safety, and potential economic benefits of oral ciprofloxacin in the treatment of infections.口服环丙沙星治疗感染的疗效、安全性及潜在经济效益。
Rev Infect Dis. 1988 May-Jun;10(3):528-43. doi: 10.1093/clinids/10.3.528.
5
Convulsions related to enoxacin.与依诺沙星相关的惊厥
Lancet. 1985 Jul 20;2(8447):161. doi: 10.1016/s0140-6736(85)90270-3.
6
Quinolones, theophylline, and diclofenac interactions with the gamma-aminobutyric acid receptor.喹诺酮类、茶碱和双氯芬酸与γ-氨基丁酸受体的相互作用。
Antimicrob Agents Chemother. 1988 Nov;32(11):1624-6. doi: 10.1128/AAC.32.11.1624.
7
Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.喹诺酮类抗菌剂对γ-氨基丁酸与大鼠脑膜受体位点结合的抑制作用。
Antimicrob Agents Chemother. 1988 Feb;32(2):190-4. doi: 10.1128/AAC.32.2.190.
8
[Adverse drug interactions between pyridonecarboxylic acids and nonsteroidal antiinflammatory drugs: convulsion after oral or intracerebral administration in mice].
Yakugaku Zasshi. 1989 Feb;109(2):119-26. doi: 10.1248/yakushi1947.109.2_119.
9
Psychotoxic effects of ofloxacin.
Pharmacopsychiatry. 1989 Jan;22(1):11-5. doi: 10.1055/s-2007-1014570.
10
Fluoroquinolones. Adverse reactions during clinical trials and postmarketing surveillance.
Pharm Weekbl Sci. 1989 Aug 25;11(4):124-7. doi: 10.1007/BF01987956.