Seibold R, Betz A
Chirurgische Klinik und Poliklinik, Klinikum Innenstadt, Ludwig-Maximilians-Universität München, Munich, Germany.
Clin Ther. 1991 Jul-Aug;13(4):457-9.
The subjects were 25 patients with osteomyelitis (n = 17) or other bone or joint infections, scheduled for surgical procedures, including debridement, sequestrectomy, and bone resection and reconstruction. Staphylococcus aureus was isolated in 22 patients, Staphylococcus epidermidis in one, Streptococcus haemolyticus in one, Pseudomonas aeruginosa in one, and a Pasteurella species in one. During surgery and for a mean of four days after surgery, each patient received 200 mg of ofloxacin intravenously twice daily (one patient received 300 mg and another received 400 mg twice daily). The patients were then given 200 mg of ofloxacin orally twice daily until the wound was healed (after a mean of 18 days). The wound was healed in all patients and no cases of reinfection occurred. It is concluded that intravenous ofloxacin given perioperatively may be more effective than oral ofloxacin in the management of osteomyelitis.
研究对象为25例患有骨髓炎（n = 17）或其他骨或关节感染的患者，他们计划接受外科手术，包括清创术、死骨切除术以及骨切除和重建术。22例患者分离出金黄色葡萄球菌，1例分离出表皮葡萄球菌，1例分离出血溶血性链球菌，1例分离出铜绿假单胞菌，1例分离出巴斯德菌属。在手术期间以及术后平均4天内，每位患者每天静脉注射200毫克氧氟沙星，每日两次（1例患者每日两次接受300毫克，另1例患者每日两次接受400毫克）。然后患者改为每日两次口服200毫克氧氟沙星，直至伤口愈合（平均18天后）。所有患者伤口均愈合，未发生再感染病例。结论是围手术期静脉注射氧氟沙星在骨髓炎治疗中可能比口服氧氟沙星更有效。
