Chen Tian-Jiao, Ji Cheng-Ye, Hu Yong-Hua
Institute of Child and Adolescent Health, Peking University, 38 Xueyuan Road, Beijing, China.
Acta Paediatr. 2009 Jun;98(6):1029-36. doi: 10.1111/j.1651-2227.2009.01257.x. Epub 2009 Mar 9.
To study the contribution of genes and environment on the variation of serum lipids and the effects of puberty.
In total, 314 same-sex twin pairs aged 5-18 years were studied. Puberty was marked physiologically by spermarche/menarche, and model fitting was used to analyse the genetic and environmental variance and its difference before and after puberty.
Lipid levels were different before and after puberty. The genetic factor had an important influence on lipid levels; the heritability estimates of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)) and apolipoprotein E (ApoE) were between 49 and 86%. The total phenotypic variances of TC, HDL, LDL, Lp(a) and ApoE decreased after puberty, mainly as a result of decrease of genetic variance, even though the common environmental variance for HDL, Lp(a) and ApoE increased.
Genes and the environment have different effects on the levels of different lipids. The shared environmental effects on lipids are very important in children. The role of puberty on lipids deserves future study.
研究基因和环境对血脂变化的贡献以及青春期的影响。
共研究了314对5至18岁的同性双胞胎。青春期以遗精/月经初潮作为生理标志，采用模型拟合分析青春期前后的遗传和环境方差及其差异。
青春期前后血脂水平不同。遗传因素对血脂水平有重要影响；总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、脂蛋白(a)（Lp(a)）和载脂蛋白E（ApoE）的遗传度估计值在49%至86%之间。青春期后，TC、HDL、LDL、Lp(a)和ApoE的总表型方差降低，主要是由于遗传方差的降低，尽管HDL、Lp(a)和ApoE的共同环境方差增加。
基因和环境对不同血脂水平有不同影响。共同环境对血脂的影响在儿童中非常重要。青春期对血脂的作用值得未来研究。
