Ay Lamise, Van Houten Vera A A, Steegers Eric A P, Hofman Albert, Witteman Jacqueline C M, Jaddoe Vincent W V, Hokken-Koelega Anita C S
The Generation R Study Group (AE006), Department of Pediatrics, Erasmus Medical Center, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands.
J Clin Endocrinol Metab. 2009 Jun;94(6):2023-30. doi: 10.1210/jc.2008-2045. Epub 2009 Mar 17.
The objectives of the study was to examine which parental, fetal, and postnatal characteristics are associated with fat and lean mass at the age of 6 months and examine the effect of growth (catch-down, catch-up) in fetal life and early infancy on fat and lean mass.
This study was embedded in the Generation R Study, a prospective cohort study from early fetal life onward. Body composition was measured by dual-energy X-ray absorptiometry in 252 infants at 6 months. Parental, fetal, and postnatal data were collected by physical and fetal ultrasound examinations and questionnaires.
Children with fetal catch-up in weight (gain in weight sd score >0.67) in the second trimester tended to have a higher fat mass percentage [FM(%)] at 6 months of age, whereas children with fetal catch-down in weight had a lower FM(%) compared with nonchangers. In the third trimester, both catch-up and catch-down in weight were associated with an increase in FM(%) at 6 months. Children with catch-down in the third trimester had a greater risk for postnatal catch-up in weight greater than 0.67 sd score. Birth weight and weight at 6 wk were positively associated with fat mass at 6 months. Postnatal catch-up in weight within 6 wk after birth had the highest association with total and truncal FM(%) at 6 months. Total and truncal FM were higher in girls.
Catch-down in weight in the third trimester was strongly associated with postnatal catch-up within 6 wk after birth, and both were associated with an increase in fat mass at the age of 6 months. Our study shows that fetal as well as postnatal growth patterns are associated with body composition in early childhood.
本研究的目的是探究哪些父母、胎儿及产后特征与6个月大时的脂肪量和瘦体量相关，并研究胎儿期和婴儿早期的生长（追赶生长、生长迟缓）对脂肪量和瘦体量的影响。
本研究纳入了“R代研究”，这是一项从胎儿早期开始的前瞻性队列研究。对252名6个月大的婴儿采用双能X线吸收法测量身体成分。通过体格检查、胎儿超声检查和问卷调查收集父母、胎儿及产后的数据。
孕中期体重出现追赶生长（体重标准差得分增加>0.67）的儿童在6个月大时往往有更高的脂肪量百分比[FM(%)]，而体重出现生长迟缓的儿童与体重无变化的儿童相比，FM(%)更低。在孕晚期，体重的追赶生长和生长迟缓均与6个月大时FM(%)的增加有关。孕晚期出现生长迟缓的儿童产后体重追赶超过0.67标准差得分的风险更大。出生体重和6周龄时的体重与6个月大时的脂肪量呈正相关。出生后6周内体重的追赶生长与6个月大时总的和躯干的FM(%)关联度最高。女孩的总的和躯干的FM更高。
孕晚期体重生长迟缓与出生后6周内的产后追赶生长密切相关，且二者均与6个月大时脂肪量的增加有关。我们的研究表明，胎儿期及产后的生长模式与儿童早期的身体成分相关。
