Khandelwal P, Jain V, Gupta A K, Kalaivani M, Paul V K
1 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
2 Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.
J Dev Orig Health Dis. 2014 Jun;5(3):189-96. doi: 10.1017/S2040174414000178.
Growth acceleration or catch-up growth (CUG) in early infancy is a plausible risk factor for later obesity and cardiovascular disease. We postulate that this risk may be mediated by an adverse programming of body composition by CUG in early infancy. The study was aimed at evaluating the association between the pattern of gain in weight and length of term low birth weight (LBW) infants from birth to 6 months, with fat mass percent (FM%) at 6 months. Term healthy singleton LBW infants were enrolled. Baby's weight and length z-scores were measured at birth and three follow-up visits. Body composition was measured by dual-energy absorptiometry at last visit. A total of 54 babies (28 boys) were enrolled. The mean birth weight and gestation were 2175±180 g and 37.6±0.6 weeks. Follow-up visits were at 1.4±0.0, 3.0±0.3 and 7.2±0.8 months. The proportion of babies who showed CUG [increase in weight for age z-score (∆WAZ)>0.67] from birth to 1.4, 3.0 and 7.2 months was 29.6, 26.4 and 48.5%, respectively. The mean FM% at 7.2 months was 16.6±7.8%. Infants with greater ∆WAZ from birth to 3 and 7.2 months had significantly greater FM% at 7.2 months after adjusting for current age, size and gender. Infants with early CUG (<1.4 months) had higher FM% than infants with no CUG. We conclude that earlier and greater increment in WAZ is positively associated with FM%.
婴儿早期的生长加速或追赶性生长（CUG）可能是日后肥胖和心血管疾病的一个风险因素。我们推测，这种风险可能是由婴儿早期CUG对身体成分的不良编程介导的。本研究旨在评估足月低出生体重（LBW）婴儿从出生到6个月的体重和身长增长模式与6个月时的体脂百分比（FM%）之间的关联。纳入了足月健康单胎LBW婴儿。在出生时和三次随访时测量婴儿的体重和身长z评分。在最后一次随访时通过双能吸收法测量身体成分。共纳入54名婴儿（28名男孩）。平均出生体重和孕周分别为2175±180 g和37.6±0.6周。随访时间分别为1.4±0.0、3.0±0.3和7.2±0.8个月。从出生到1.4、3.0和7.2个月出现CUG [年龄别体重z评分增加（∆WAZ）>0.67]的婴儿比例分别为29.6%、26.4%和48.5%。7.2个月时的平均FM%为16.6±7.8%。在调整了当前年龄、体型和性别后，从出生到3个月和7.2个月∆WAZ较大的婴儿在7.2个月时的FM%显著更高。早期出现CUG（<1.4个月）的婴儿的FM%高于未出现CUG的婴儿。我们得出结论，WAZ早期和更大幅度的增加与FM%呈正相关。
