Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India.
Indian J Dermatol Venereol Leprol. 2009 Mar-Apr;75(2):136-41. doi: 10.4103/0378-6323.48657.
Elimination of allergens/topical medications causing contact dermatitis in venous eczema, which poses a significant problem in its chronicity and treatment, provides the basis for better therapeutic outcome. Our objective was to determine the pattern of contact sensitization in venous eczema patients in Himachal Pradesh (India).
Thirty-four patients (M:F, 31:3) and 10 controls (M:F, 6:4) were patch tested with Indian standard series and 10 commonly used topical medicaments.
Positive patch test results were seen in 50% (M:F, 16:1) of the patients. Common allergens were Fragrance mix (15%), p-phenylendiamine (15%), nickel (9%), wool alcohol (9%), chinoform (9%), balsum of Peru (5%), cobalt chloride (5%), potassium dichromate (3%), epoxy resin (3%), thiuram mix (3%) and formaldehyde (3%). Only sisomycin and miconazole among the topical medications elicited a positive patch test reaction in 3 and 5% patients, respectively. Neomycin contact sensitivity was not seen in any of the patients. One patient who had exacerbation of venous eczema following accidental application of topical diclofenac showed a positive patch test reaction to it.
Patch test should be used to identify the topical agents that may be responsible for perpetuation or aggravation of eczema, especially in patients who do not improve despite adequate treatment of other underlying cause(s).
消除静脉性湿疹中导致接触性皮炎的过敏原/局部药物，这对其慢性和治疗提出了重大挑战，为更好的治疗效果提供了基础。我们的目的是确定印度喜马偕尔邦静脉性湿疹患者的接触致敏模式。
对 34 名患者（男女比为 31:3）和 10 名对照者（男女比为 6:4）进行了印度标准系列和 10 种常用局部药物的斑贴试验。
50%（男女比为 16:1）的患者出现阳性斑贴试验结果。常见的过敏原包括香料混合物（15%）、对苯二胺（15%）、镍（9%）、羊毛醇（9%）、氯仿（9%）、秘鲁香脂（5%）、氯化钴（5%）、重铬酸钾（3%）、环氧树脂（3%）、噻二唑混合物（3%）和甲醛（3%）。只有在 3%和 5%的患者中，西索米星和米康唑这两种局部药物分别引起阳性斑贴试验反应。没有患者出现新霉素接触敏感性。一名患者在意外使用局部双氯芬酸后静脉性湿疹加重，对其出现阳性斑贴试验反应。
应使用斑贴试验来识别可能导致湿疹持续或加重的局部药物，特别是在其他潜在病因得到充分治疗后仍未改善的患者。
