同型胱氨酸尿症患者在维生素B6治疗期间未出现感觉神经病变。
No sensory neuropathy during pyridoxine treatment in homocystinuria.
作者信息
Mpofu C, Alani S M, Whitehouse C, Fowler B, Wraith J E
机构信息
Willink Biochemical Genetics Unit, Royal Manchester Children's Hospital.
出版信息
Arch Dis Child. 1991 Sep;66(9):1081-2. doi: 10.1136/adc.66.9.1081.
Abstract
Seventeen patients with cystathionine synthase deficiency homocystinuria were examined clinically and neurophysiologically for evidence of sensory neuropathy. All had received high dose pyridoxine (vitamin B-6) for many years. Absence of neurological disturbance in all cases suggests long term treatment with pyridoxine in the dosages used in homocystinuric patients is not harmful.
摘要
对17例患有胱硫醚合酶缺乏型同型胱氨酸尿症的患者进行了临床和神经生理学检查，以寻找感觉神经病变的证据。所有患者均已接受大剂量吡哆醇（维生素B-6）治疗多年。所有病例均无神经功能障碍，这表明以同型胱氨酸尿症患者所使用的剂量长期使用吡哆醇并无危害。
相似文献
1
No sensory neuropathy during pyridoxine treatment in homocystinuria.同型胱氨酸尿症患者在维生素B6治疗期间未出现感觉神经病变。
Arch Dis Child. 1991 Sep;66(9):1081-2. doi: 10.1136/adc.66.9.1081.
2
Regressive pyridoxine-induced sensory neuronopathy in a patient with homocystinuria.一名同型胱氨酸尿症患者发生的维生素B6缺乏所致的退行性感觉神经元病。
BMJ Case Rep. 2018 Jun 28;2018:bcr-2018-225059. doi: 10.1136/bcr-2018-225059.
3
The intellectual abilities of early-treated individuals with pyridoxine-nonresponsive homocystinuria due to cystathionine beta-synthase deficiency.因胱硫醚β-合酶缺乏导致的吡哆醇无反应性同型胱氨酸尿症早期治疗个体的智力能力。
J Inherit Metab Dis. 2001 Aug;24(4):437-47. doi: 10.1023/a:1010525528842.
4
Electroencephalographic abnormalities in homocystinuria due to cystathionine synthase deficiency.由于胱硫醚合成酶缺乏导致的同型胱氨酸尿症中的脑电图异常。
Clin Neurol Neurosurg. 1983;85(3):165-8. doi: 10.1016/0303-8467(83)90046-x.
5
The molecular basis of cystathionine beta-synthase deficiency in Australian patients: genotype-phenotype correlations and response to treatment.澳大利亚患者中胱硫醚β-合酶缺乏症的分子基础：基因型-表型相关性及治疗反应
Hum Mutat. 2002 Aug;20(2):117-26. doi: 10.1002/humu.10104.
6
Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years.胱硫醚β-合酶缺乏症的治疗策略：威林克生化遗传学研究室过去30年的经验
Eur J Pediatr. 1998 Apr;157 Suppl 2:S71-6. doi: 10.1007/pl00014308.
7
[A case report of pyridoxine-responsive homocystinuria].[一例维生素B6反应性同型胱氨酸尿症病例报告]
Med Pregl. 1999 Nov-Dec;52(11-12):501-4.
8
Homocystinuria. Reduced folate levels during pyridoxine treatment.同型胱氨酸尿症。维生素B6治疗期间叶酸水平降低。
Arch Dis Child. 1973 Jan;48(1):58-62. doi: 10.1136/adc.48.1.58.
9
Homocystinuria due to cystathionine synthase deficiency: the effect of pyridoxine.由于胱硫醚合成酶缺乏所致的同型胱氨酸尿症：维生素B6的作用。
J Clin Invest. 1970 Sep;49(9):1762-73. doi: 10.1172/JCI106394.
10
Treatment of homocystinuria with pyridoxine. A preliminary study.用吡哆醇治疗同型胱氨酸尿症。一项初步研究。
Arch Dis Child. 1969 Jun;44(235):387-92. doi: 10.1136/adc.44.235.387.
引用本文的文献
1
Cystathionine β-Synthase Deficiency in the E-HOD Registry-Part II: Dietary and Pharmacological Treatment.E-HOD注册研究中的胱硫醚β-合酶缺乏症 - 第二部分：饮食和药物治疗
J Inherit Metab Dis. 2025 Jan;48(1):e12844. doi: 10.1002/jimd.12844.
2
Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity.维生素 B-6 诱导的神经病：探讨吡哆醇毒性的机制。
Adv Nutr. 2021 Oct 1;12(5):1911-1929. doi: 10.1093/advances/nmab033.
3
Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency.胱硫醚β-合酶缺乏症的诊断与管理指南。
J Inherit Metab Dis. 2017 Jan;40(1):49-74. doi: 10.1007/s10545-016-9979-0. Epub 2016 Oct 24.
4
Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control.糖尿病周围神经病变管理中的代谢纠正：超越症状控制改善临床效果。
Curr Clin Pharmacol. 2011 Nov;6(4):260-73. doi: 10.2174/157488411798375967.
5
Homocystinuria.同型胱氨酸尿症
BMJ. 1996 Oct 26;313(7064):1025-6. doi: 10.1136/bmj.313.7064.1025.
6
Sensory neuropathy and vitamin B6 treatment in homocystinuria.同型胱氨酸尿症中的感觉神经病与维生素B6治疗
Eur J Pediatr. 1993 Mar;152(3):271. doi: 10.1007/BF01956164.
本文引用的文献
1
Plasma content of B6 vitamers and its relationship to hepatic vitamin B6 metabolism.血浆中维生素B6各形式的含量及其与肝脏维生素B6代谢的关系。
J Clin Invest. 1980 Oct;66(4):688-95. doi: 10.1172/JCI109906.
2
Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome.滥用吡哆醇所致感觉神经病。一种新的维生素过多综合征。
N Engl J Med. 1983 Aug 25;309(8):445-8. doi: 10.1056/NEJM198308253090801.
3
Plasma pyridoxal-5-phosphate level as risk index for coronary artery disease.血浆磷酸吡哆醛-5-磷酸水平作为冠状动脉疾病的风险指标。
Atherosclerosis. 1985 Jun;55(3):357-61. doi: 10.1016/0021-9150(85)90113-3.
4
Safety of pyridoxine--a review of human and animal studies.吡哆醇的安全性——对人体和动物研究的综述
Toxicol Lett. 1986 Dec;34(2-3):129-39. doi: 10.1016/0378-4274(86)90202-x.
5
Sensory neuropathy with low-dose pyridoxine.
Neurology. 1985 Oct;35(10):1466-8. doi: 10.1212/wnl.35.10.1466.
Zotero 插件