Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D, Brown M J
N Engl J Med. 1983 Aug 25;309(8):445-8. doi: 10.1056/NEJM198308253090801.
We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the central nervous system was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, this report indicates that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin.
我们描述了7名成年人，他们在每日大量摄入吡哆醇（维生素B6）后出现共济失调和严重的感觉神经系统功能障碍。其中4人严重残疾；停药后均有改善。无力并非此病症的特征，临床检查显示中枢神经系统未受影响。尽管大剂量服用吡哆醇已被公众广泛接受，但本报告表明，它可导致感觉神经病变或神经元病变综合征，因此应该为这种被广泛滥用的维生素的使用制定安全指南。
