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False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen.急性肺组织胞浆菌病中组织胞浆菌抗原假阴性：血清蛋白超滤和热变性尿液浓缩在检测组织胞浆菌抗原中的价值
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本文引用的文献

1
Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results.通过对结果为假阴性的样本进行超滤检测荚膜组织胞浆菌抗原尿
Clin Vaccine Immunol. 2008 Apr;15(4):726-8. doi: 10.1128/CVI.00493-07. Epub 2008 Feb 27.
2
Detection of histoplasma antigen by a quantitative enzyme immunoassay.通过定量酶免疫测定法检测组织胞浆菌抗原。
Clin Vaccine Immunol. 2007 Dec;14(12):1587-91. doi: 10.1128/CVI.00071-07. Epub 2007 Oct 3.
3
Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America.组织胞浆菌病患者管理临床实践指南：美国传染病学会2007年更新版
Clin Infect Dis. 2007 Oct 1;45(7):807-25. doi: 10.1086/521259. Epub 2007 Aug 27.
4
Improvements in diagnosis of histoplasmosis.组织胞浆菌病诊断的改进。
Expert Opin Biol Ther. 2006 Nov;6(11):1207-21. doi: 10.1517/14712598.6.11.1207.
5
Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind.在印第安纳州印第安纳波利斯市的一次疫情期间通过抗原检测诊断组织胞浆菌病
Arch Pathol Lab Med. 1994 Dec;118(12):1205-8.
6
A large urban outbreak of histoplasmosis: clinical features.组织胞浆菌病在大城市的大规模暴发：临床特征
Ann Intern Med. 1981 Mar;94(3):331-7. doi: 10.7326/0003-4819-94-3-331.
7
Unusual manifestations of histoplasmosis in childhood.儿童组织胞浆菌病的不寻常表现。
Pediatrics. 1983 Jul;72(1):99-105.
8
Differentiation of lymphoma from histoplasmosis in children with mediastinal masses.纵隔肿块患儿淋巴瘤与组织胞浆菌病的鉴别诊断
J Pediatr. 1984 May;104(5):706-9. doi: 10.1016/s0022-3476(84)80948-8.
9
Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens.通过检测血清和尿液标本中的荚膜组织胞浆菌抗原诊断播散性组织胞浆菌病。
N Engl J Med. 1986 Jan 9;314(2):83-8. doi: 10.1056/NEJM198601093140205.
10
Disseminated histoplasmosis of infancy.婴儿播散性组织胞浆菌病。
Pediatr Infect Dis J. 1988 Nov;7(11):799-805. doi: 10.1097/00006454-198811000-00012.

急性肺组织胞浆菌病中组织胞浆菌抗原假阴性：血清蛋白超滤和热变性尿液浓缩在检测组织胞浆菌抗原中的价值

False-negative Histoplasma antigen in acute pulmonary histoplasmosis: the value of urinary concentration by ultrafiltration and heat denaturation of serum proteins in detection of Histoplasma antigen.

作者信息

Srinivasan Ashok, Kleiman Martin B, Debelenko Larisa, Stokes Dennis C, De Vincenzo John, Wheat Joseph L

机构信息

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

出版信息

Pediatr Infect Dis J. 2009 May;28(5):447-9. doi: 10.1097/INF.0b013e318193ecc1.

DOI:10.1097/INF.0b013e318193ecc1
PMID:19295461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5702545/
Abstract

We report an infant with localized pulmonary histoplasmosis in whom Histoplasma antibody assays, quantitative Histoplasma urine and serum antigen concentrations, and histopathologic findings of a mediastinal mass were nondiagnostic. A provisional diagnosis of histoplasmosis was established by using laboratory methods that increase the sensitivity of the antigen assay using ultrafiltration of urine and ethylenediaminetetraacetic acid/heat denaturation of serum proteins.

摘要

我们报告了一名患有局限性肺组织胞浆菌病的婴儿，其组织胞浆菌抗体检测、尿和血清中组织胞浆菌抗原定量浓度以及纵隔肿块的组织病理学检查结果均无法确诊。通过使用实验室方法建立了组织胞浆菌病的初步诊断，这些方法通过尿液超滤和血清蛋白的乙二胺四乙酸/热变性提高了抗原检测的灵敏度。