Coleman Sydney R, Sachdeva Kulveen, Egbert Barbara M, Preciado Jessica, Allison John
Department of Surgery, NYU School of Medicine, 44 Hudson Street, New York, NY 10013, USA.
Aesthetic Plast Surg. 2009 Jul;33(4):482-8. doi: 10.1007/s00266-008-9286-8. Epub 2009 Mar 19.
Cryolipolysis provides a method for noninvasive fat reduction that significantly reduces subcutaneous fat in a pig model without apparent damage to skin and surrounding structures. This study aimed to determine whether fat reduction in humans caused by cold exposure is associated with alteration in local sensory function or nerve fibers.
In this study, 10 subjects were treated with a prototype cooling device. Fat reduction was assessed in 9 of the 10 subjects via ultrasound before treatment and at the follow-up visit. Sensory function was assessed by neurologic evaluation (n = 9), and biopsies (n = 1) were collected for nerve staining.
Treatment resulted in a normalized fat layer reduction of 20.4% at 2 months and 25.5% at 6 months after treatment. Transient reduction in sensation occurred in six of nine subjects assessed by neurologic evaluation. However, all sensation returned by a mean of 3.6 weeks after treatment. Biopsies showed no long-term change in nerve fiber structure. There were no lasting sensory alterations or observations of skin damage in any of the subjects evaluated.
Noninvasive cryolipolysis results in substantial fat reduction within 2 months of treatment without damage to skin. The procedure is associated with modest reversible short-term changes in the function of peripheral sensory nerves.
冷冻溶脂术提供了一种非侵入性减脂方法，在猪模型中可显著减少皮下脂肪，且对皮肤和周围结构无明显损伤。本研究旨在确定冷暴露导致的人体脂肪减少是否与局部感觉功能或神经纤维改变有关。
在本研究中，10名受试者接受了一种原型冷却装置治疗。10名受试者中的9名在治疗前和随访时通过超声评估脂肪减少情况。通过神经学评估（n = 9）评估感觉功能，并采集活检样本（n = 1）进行神经染色。
治疗后2个月脂肪层减少量标准化为20.4%，6个月时为25.5%。在通过神经学评估的9名受试者中，有6名出现感觉短暂减退。然而，所有感觉在治疗后平均3.6周恢复。活检显示神经纤维结构无长期变化。在评估的任何受试者中均未出现持久的感觉改变或皮肤损伤观察结果。
非侵入性冷冻溶脂术在治疗后2个月内可显著减少脂肪，且不会损伤皮肤。该手术与外周感觉神经功能的适度可逆短期变化有关。
