人类非洲锥虫病脑膜脑炎中CXCL-13水平升高。
Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis.
作者信息
Courtioux Bertrand, Pervieux Lynda, Vatunga Gedeao, Marin Benoit, Josenando Théophile, Jauberteau-Marchan Marie-Odile, Bouteille Bernard, Bisser Sylvie
机构信息
Institut de Neurologie Tropicale, Université de Limoges, Limoges, France.
出版信息
Trop Med Int Health. 2009 May;14(5):529-34. doi: 10.1111/j.1365-3156.2009.02263.x. Epub 2009 Mar 2.
OBJECTIVES
To determine the role of the B-cell attracting chemokine CXCL-13, which may initiate B-cell trafficking and IgM production in diagnosing HAT meningo-encephalitis.
METHODS
We determined CXCL-13 levels by ELISA on paired sera and CSF of 26 patients from Angola and of 16 controls (six endemic and ten non-endemic). Results were compared to standard stage determination markers and IgM intrathecal synthesis.
RESULTS
CXCL-13 levels in patients' sera had a median value of 386.6 pg/ml and increased levels were associated with presence of trypanosomes in the CSF but not with other stage markers. CXCL-13 levels in patients' CSF had a median value of 80.9 pg/ml and increased levels were associated with all standard stage determination markers and IgM intrathecal synthesis.
CONCLUSION
CXCL-13 levels in CSF increased significantly during the course of HAT. Hence the value of CXCL-13 for diagnosis, follow-up or as a marker of disease severity should be tested in a well-defined cohort study.
目的
确定B细胞趋化因子CXCL - 13在诊断非洲锥虫病脑膜脑炎中的作用，该因子可能启动B细胞迁移和IgM产生。
方法
我们采用酶联免疫吸附测定法（ELISA）检测了26名来自安哥拉的患者以及16名对照者（6名地方病患者和10名非地方病患者）配对血清和脑脊液中的CXCL - 13水平。将结果与标准分期测定标志物和IgM鞘内合成情况进行比较。
结果
患者血清中CXCL - 13水平的中位数为386.6 pg/ml，其水平升高与脑脊液中锥虫的存在有关，但与其他分期标志物无关。患者脑脊液中CXCL - 13水平的中位数为80.9 pg/ml，其水平升高与所有标准分期测定标志物及IgM鞘内合成有关。
结论
在非洲锥虫病病程中，脑脊液中的CXCL - 13水平显著升高。因此，应在一项明确界定的队列研究中检测CXCL - 13在诊断、随访或作为疾病严重程度标志物方面的价值。
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