Castro Luísa, Goldani Luciano Z
Section of Infectious Diseases, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre RS 90035-003, Brazil.
Trop Doct. 2009 Apr;39(2):83-5. doi: 10.1258/td.2008.080069.
We conducted a study to determine the role of iron, folate and vitamin B12 in HIV-infected patients with anaemia attending a tertiary-care hospital in southern Brazil. Low serum folate levels were found in 14 (41%) HIV-infected patients; parameters of iron deficiency such as low transferring saturation index and ferritin in 10 (30%); and combined folate and iron deficiency in five (14%). Vitamin B12 deficiency was found in only two (6%) patients who presented with mean corpuscular volumes within the normal range. Our study has shown that folate and iron deficiency were frequently detected in HIV-infected patients at our institution, and should be considered in the differential diagnosis of anaemia in all HIV-infected patients independent of their HIV stage of progression.
我们开展了一项研究，以确定铁、叶酸和维生素B12在巴西南部一家三级医院就诊的贫血HIV感染患者中的作用。在14名（41%）HIV感染患者中发现血清叶酸水平较低；10名（30%）患者存在缺铁参数，如转铁蛋白饱和度指数和铁蛋白较低；5名（14%）患者存在叶酸和铁联合缺乏。仅在2名（6%）平均红细胞体积在正常范围内的患者中发现维生素B12缺乏。我们的研究表明，在我们机构的HIV感染患者中经常检测到叶酸和铁缺乏，在所有HIV感染患者的贫血鉴别诊断中均应予以考虑，无论其HIV疾病进展阶段如何。
