Chen Honglei, Mosley Thomas H, Alonso Alvaro, Huang Xuemei
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Am J Epidemiol. 2009 May 1;169(9):1064-9. doi: 10.1093/aje/kwp033. Epub 2009 Mar 18.
Higher plasma urate concentration has been linked to lower risk of Parkinson's disease in men, but data are lacking on women and African Americans. The authors examined plasma urate in relation to Parkinson's disease in the biracial, population-based Atherosclerosis Risk in Communities (ARIC) cohort. Between 1987 and 1989, 15,792 participants, aged 45-64 years, were recruited from 4 US communities and have since been followed with 3 triennial visits and annual surveillance. Plasma urate was measured at visits 1 and 2, and the concentrations were highly correlated. From visit 1 through 2004, 95 potential cases of Parkinson's disease were identified from multiple sources. Odds ratios and 95% confidence intervals were calculated from multivariate logistic regression models. Plasma urate concentration was inversely associated with Parkinson's disease occurrence. The odds ratios between extreme quartiles of plasma urate were 0.4 (95% confidence interval: 0.2, 0.8) in the overall analysis, 0.3 (95% confidence interval: 0.1, 0.7) for men, and 0.4 (95% confidence interval: 0.2, 1.0) for Caucasians. Such an association was also suggested among women and African Americans but was not statistically significant because of small sample sizes. These data support the previous finding that urate may be a protective factor against Parkinson's disease.
较高的血浆尿酸盐浓度与男性患帕金森病的较低风险相关，但关于女性和非裔美国人的数据尚缺。作者在以社区为基础的双种族动脉粥样硬化风险研究（ARIC）队列中，研究了血浆尿酸盐与帕金森病的关系。1987年至1989年期间，从美国4个社区招募了15792名年龄在45至64岁之间的参与者，此后对其进行了3次每三年一次的随访和年度监测。在第1次和第2次随访时测量血浆尿酸盐，其浓度高度相关。从第1次随访到2004年，通过多种来源确定了95例帕金森病潜在病例。通过多变量逻辑回归模型计算比值比和95%置信区间。血浆尿酸盐浓度与帕金森病的发生呈负相关。在总体分析中，血浆尿酸盐极端四分位数之间的比值比为0.4（95%置信区间：0.2，0.8），男性为0.3（95%置信区间：0.1，0.7），白人为0.4（95%置信区间：0.2，1.0）。在女性和非裔美国人中也提示有这种关联，但由于样本量小，未达到统计学显著性。这些数据支持了先前的发现，即尿酸盐可能是预防帕金森病的一个保护因素。
