Birmingham VA Medical Center 700 South 19th Street, Birmingham, AL 35233, USA.
Arthritis Res Ther. 2012 Jan 6;14(1):R4. doi: 10.1186/ar3552.
Findings that African-American race/ethnicity is associated with higher concentrations of serum urate have not been adjusted for possible confounding factors or have not explored this question as a primary outcome. We tested this hypothesis in a bi-racial cohort of younger African-American and white men and women.
Data from 5,049 participants at the Coronary Artery Risk Development in Young Adults (CARDIA) cohort baseline (1985 to 1986) and follow-up for up to 20 years of individuals without hyperuricemia (defined as a serum urate of 6.8 mg/dL or more) at baseline were utilized. We determined associations between race, serum urate and the development of hyperuricemia in sex-specific cross-sectional and longitudinal analyses. Confounding factors examined included: age at enrollment, body mass index, development of hypertension, glomerular filtration rate, medication use, diet and alcohol intake and menopausal symptoms in women.
Referent to whites, African-American men and women had significantly lower concentrations of serum urate at baseline. African-American men had an essentially equal risk of developing incident hyperuricemia during follow-up compared with white men (multivariable adjusted HR = 1.12 (0.88 to 1.40)). African-American women developed a significantly increased risk of hyperuricemia when compared to white women (HR = 2.31 (1.34 to 3.99)).
Young African-American men and women had lower concentrations of serum urate than whites. During longitudinal follow-up, African-American women had a significantly increased risk of developing hyperuricemia when compared with white women, a difference that was not observed in men. Differences in production of serum urate or a more rapid decline in fractional excretion of serum urate are potential, albeit still unproven, explanations for these findings in African-American women.
非洲裔美国人种族与血清尿酸浓度较高有关的发现，尚未调整可能存在的混杂因素，也未将此问题作为主要结果进行探讨。我们在一个由年轻的非裔美国人和白种人男性和女性组成的双种族队列中检验了这一假设。
利用来自冠状动脉风险发展在年轻人（CARDIA）队列基线（1985 年至 1986 年）和多达 20 年的随访数据，基线时无高尿酸血症（定义为血清尿酸 6.8mg/dL 或更高）的个体。我们在男女特定的横断面和纵向分析中确定了种族、血清尿酸与高尿酸血症发展之间的关联。检查的混杂因素包括：入组时的年龄、体重指数、高血压的发展、肾小球滤过率、药物使用、饮食和酒精摄入以及女性的更年期症状。
与白人相比，非裔美国男性和女性的基线血清尿酸浓度明显较低。非裔美国男性在随访期间发生高尿酸血症的风险与白人男性基本相同（多变量调整后的 HR = 1.12（0.88 至 1.40））。与白人女性相比，非裔美国女性发生高尿酸血症的风险显著增加（HR = 2.31（1.34 至 3.99））。
年轻的非裔美国男性和女性的血清尿酸浓度低于白人。在纵向随访中，与白人女性相比，非裔美国女性发生高尿酸血症的风险显著增加，而男性则没有观察到这种差异。血清尿酸的产生差异或血清尿酸的分数排泄率下降更快是这些非裔美国女性发现的潜在（尽管尚未证实）解释。
