急性缺血性卒中CT灌注成像的理论基础与技术实现，第2部分：技术实现
Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations.
作者信息
Konstas A A, Goldmakher G V, Lee T-Y, Lev M H
机构信息
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
AJNR Am J Neuroradiol. 2009 May;30(5):885-92. doi: 10.3174/ajnr.A1492. Epub 2009 Mar 19.
Abstract
CT perfusion (CTP) is a functional imaging technique that provides important information about capillary-level hemodynamics of the brain parenchyma and is a natural complement to the strengths of unenhanced CT and CT angiography in the evaluation of acute stroke, vasospasm, and other neurovascular disorders. CTP is critical in determining the extent of irreversibly infarcted brain tissue (infarct "core") and the severely ischemic but potentially salvageable tissue ("penumbra"). This is achieved by generating parametric maps of cerebral blood flow, cerebral blood volume, and mean transit time.
摘要
CT灌注成像（CTP）是一种功能成像技术，可提供有关脑实质毛细血管水平血流动力学的重要信息，是平扫CT和CT血管造影在评估急性中风、血管痉挛及其他神经血管疾病时优势的自然补充。CTP对于确定不可逆梗死脑组织（梗死“核心”）以及严重缺血但可能挽救的组织（“半暗带”）的范围至关重要。这是通过生成脑血流量、脑血容量和平均通过时间的参数图来实现的。
相似文献
1
Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations.急性缺血性卒中CT灌注成像的理论基础与技术实现，第2部分：技术实现
AJNR Am J Neuroradiol. 2009 May;30(5):885-92. doi: 10.3174/ajnr.A1492. Epub 2009 Mar 19.
2
Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis.急性缺血性脑卒中CT灌注成像的理论基础与技术实现，第1部分：理论基础
AJNR Am J Neuroradiol. 2009 Apr;30(4):662-8. doi: 10.3174/ajnr.A1487. Epub 2009 Mar 6.
3
CT perfusion mean transit time maps optimally distinguish benign oligemia from true "at-risk" ischemic penumbra, but thresholds vary by postprocessing technique.CT 灌注平均通过时间图最佳地区分良性低灌注与真正的“危险”缺血半影区，但阈值因后处理技术而异。
AJNR Am J Neuroradiol. 2012 Mar;33(3):545-9. doi: 10.3174/ajnr.A2809. Epub 2011 Dec 22.
4
Defining acute ischemic stroke tissue pathophysiology with whole brain CT perfusion.用全脑CT灌注技术定义急性缺血性脑卒中组织病理生理学。
J Neuroradiol. 2014 Dec;41(5):307-15. doi: 10.1016/j.neurad.2013.11.006. Epub 2014 Jan 13.
5
Value of perfusion computed tomography in acute ischemic stroke: diagnosis of infarct core and penumbra.灌注计算机断层扫描在急性缺血性卒中中的价值：梗死核心与半暗带的诊断
J Comput Assist Tomogr. 2013 Sep-Oct;37(5):645-9. doi: 10.1097/RCT.0b013e31829866fc.
6
Whole-brain CT perfusion: reliability and reproducibility of volumetric perfusion deficit assessment in patients with acute ischemic stroke.全脑 CT 灌注：急性缺血性脑卒中患者容积灌注缺损评估的可靠性和可重复性。
Neuroradiology. 2013 Jul;55(7):827-35. doi: 10.1007/s00234-013-1179-0. Epub 2013 Apr 9.
7
Differences in CT perfusion summary maps for patients with acute ischemic stroke generated by 2 software packages.两种软件包生成的急性缺血性脑卒中患者 CT 灌注总结图的差异。
AJNR Am J Neuroradiol. 2012 Dec;33(11):2074-80. doi: 10.3174/ajnr.A3110. Epub 2012 May 3.
8
Stroke and CT Perfusion.中风与CT灌注成像
Radiol Technol. 2012 May-Jun;83(5):467CT-486CT.
9
CT Imaging Computed Tomography/Computed Tomography Angiography/Perfusion in Acute Ischemic Stroke and Vasospasm.CT 成像 计算机断层扫描/计算机断层血管造影/灌注在急性缺血性卒中及血管痉挛中的应用。
Neuroimaging Clin N Am. 2024 May;34(2):175-189. doi: 10.1016/j.nic.2024.01.004. Epub 2024 Feb 29.
10
Feasibility of deconvolution-based multiphase CT angiography perfusion maps in acute ischemic stroke: Simulation and concordance with CT perfusion.基于去卷积的多相 CT 血管造影灌注图在急性缺血性脑卒中的可行性：模拟与 CT 灌注的一致性。
J Stroke Cerebrovasc Dis. 2022 Dec;31(12):106844. doi: 10.1016/j.jstrokecerebrovasdis.2022.106844. Epub 2022 Oct 29.
引用本文的文献
1
Time series-derived fractal dimension of CT perfusion in acute ischemic stroke: a promising marker for hypoperfused tissue quantification.急性缺血性卒中CT灌注的时间序列衍生分形维数：一种用于低灌注组织定量的有前景的标志物。
Int J Comput Assist Radiol Surg. 2025 Aug 18. doi: 10.1007/s11548-025-03500-3.
2
Evolution of CT perfusion software in stroke imaging: from deconvolution to artificial intelligence.中风成像中CT灌注软件的发展：从去卷积到人工智能。
Eur Radiol. 2025 Jul 9. doi: 10.1007/s00330-025-11779-8.
3
Evaluating the effect of noise reduction strategies in CT perfusion imaging for predicting infarct core with deep learning.评估CT灌注成像中降噪策略对深度学习预测梗死核心的影响。
Neuroradiol J. 2025 Jan 9:19714009251313517. doi: 10.1177/19714009251313517.
4
Deep learning biomarker of chronometric and biological ischemic stroke lesion age from unenhanced CT.基于平扫CT的计时性和生物性缺血性脑卒中病变年龄的深度学习生物标志物
NPJ Digit Med. 2024 Dec 6;7(1):338. doi: 10.1038/s41746-024-01325-z.
5
CT perfusion imaging in aneurysmal subarachnoid hemorrhage. State of the art.动脉瘤性蛛网膜下腔出血的CT灌注成像。现状。
Front Radiol. 2024 Oct 7;4:1445676. doi: 10.3389/fradi.2024.1445676. eCollection 2024.
6
Association of critical hypoperfusion biomarkers on CT with futile recanalization and poor outcome after mechanical thrombectomy in acute ischemic stroke.CT 显示的关键低灌注生物标志物与急性缺血性脑卒中机械取栓后无效再通和不良结局的相关性。
BMC Neurol. 2024 Oct 21;24(1):406. doi: 10.1186/s12883-024-03911-w.
7
Mechanical Thrombectomy in the Late Presentation of Anterior Circulation Large Vessel Occlusion Stroke: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.前循环大血管闭塞性卒中延迟就诊时的机械取栓术：血管与介入神经病学学会指南与实践标准委员会的指南
Stroke Vasc Interv Neurol. 2023 Jan;3(1). doi: 10.1161/SVIN.122.000512. Epub 2022 Nov 30.
8
CTP for the Screening of Vasospasm and Delayed Cerebral Ischemia in Aneurysmal SAH: A Systematic Review and Meta-analysis.CTP 用于筛查动脉瘤性蛛网膜下腔出血后血管痉挛和迟发性脑缺血：系统评价和荟萃分析。
AJNR Am J Neuroradiol. 2024 Jul 8;45(7):871-878. doi: 10.3174/ajnr.A8249.
9
Pulmonary CT perfusion robustly measures cardiac output in the context of multilevel pulmonary occlusion: a porcine study.多层肺阻断时肺部 CT 灌注能可靠地测量心输出量：一项猪研究。
Eur Radiol Exp. 2024 Mar 22;8(1):51. doi: 10.1186/s41747-024-00431-7.
10
Deep Learning for Perfusion Cerebral Blood Flow (CBF) and Volume (CBV) Predictions and Diagnostics.深度学习在灌注脑血流（CBF）和体积（CBV）预测和诊断中的应用。
Ann Biomed Eng. 2024 Jun;52(6):1568-1575. doi: 10.1007/s10439-024-03471-7. Epub 2024 Feb 24.
本文引用的文献
1
Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 1: Theoretic basis.急性缺血性脑卒中CT灌注成像的理论基础与技术实现，第1部分：理论基础
AJNR Am J Neuroradiol. 2009 Apr;30(4):662-8. doi: 10.3174/ajnr.A1487. Epub 2009 Mar 6.
2
Acute stroke imaging research roadmap.急性卒中成像研究路线图。
AJNR Am J Neuroradiol. 2008 May;29(5):e23-30. doi: 10.1161/STROKEAHA.107.512319.
3
White matter thresholds for ischemic penumbra and infarct core in patients with acute stroke: CT perfusion study.急性卒中患者缺血半暗带和梗死核心的白质阈值：CT灌注研究
Radiology. 2008 Jun;247(3):818-25. doi: 10.1148/radiol.2473070551. Epub 2008 Apr 18.
4
Acute stroke imaging research roadmap.急性中风成像研究路线图。
Stroke. 2008 May;39(5):1621-8. doi: 10.1161/STROKEAHA.107.512319. Epub 2008 Apr 10.
5
Multidetector computed tomography for the detection of left atrial appendage thrombus: a comparative study with transesophageal echocardiography.多排螺旋计算机断层扫描用于检测左心耳血栓：与经食管超声心动图的对比研究。
J Comput Assist Tomogr. 2007 Nov-Dec;31(6):905-9. doi: 10.1097/rct.0b013e31803c55e3.
6
Left atrial appendage filling defects identified by multidetector computed tomography in patients undergoing radiofrequency pulmonary vein antral isolation: a comparison with transesophageal echocardiography.多排螺旋计算机断层扫描在接受射频肺静脉前庭隔离术患者中发现的左心耳充盈缺损：与经食管超声心动图的比较
Am Heart J. 2007 Dec;154(6):1199-205. doi: 10.1016/j.ahj.2007.08.004. Epub 2007 Sep 14.
7
CT-perfusion imaging of the human brain: advanced deconvolution analysis using circulant singular value decomposition.人脑的CT灌注成像：使用循环奇异值分解的先进去卷积分析
Comput Med Imaging Graph. 2008 Jan;32(1):67-77. doi: 10.1016/j.compmedimag.2007.09.004.
8
Comparison of 10 different magnetic resonance perfusion imaging processing methods in acute ischemic stroke: effect on lesion size, proportion of patients with diffusion/perfusion mismatch, clinical scores, and radiologic outcomes.急性缺血性卒中10种不同磁共振灌注成像处理方法的比较：对病变大小、弥散/灌注不匹配患者比例、临床评分及影像学结果的影响
Stroke. 2007 Dec;38(12):3158-64. doi: 10.1161/STROKEAHA.107.483842. Epub 2007 Nov 1.
9
Radiation dose-reduction strategies for neuroradiology CT protocols.神经放射学CT检查方案的辐射剂量降低策略。
AJNR Am J Neuroradiol. 2007 Oct;28(9):1628-32. doi: 10.3174/ajnr.A0814. Epub 2007 Sep 24.
10
Effect of the arterial input function on the measured perfusion values and infarct volumetric in acute cerebral ischemia evaluated by perfusion computed tomography.动脉输入函数对通过灌注计算机断层扫描评估的急性脑缺血中测量的灌注值和梗死体积的影响。
Invest Radiol. 2007 Mar;42(3):147-56. doi: 10.1097/01.rli.0000252486.79800.a7.
Zotero 插件