Cachovan Georg, Nergiz Ibrahim, Thuss Uwe, Siefert Hans-Martin, Sobottka Ingo, Oral Okhan, Platzer Ursula, Dogan-Onur Ozen
Center of Oral and Dental Medicine, Department of Restorative and Preventive Dentistry, University of Hamburg, Hamburg, Germany.
Acta Odontol Scand. 2009;67(3):182-6. doi: 10.1080/00016350902787564.
Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats.
Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis.
The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13.
Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.
基于其体外活性和活性谱，新型8-甲氧基喹诺酮类抗生素莫西沙星（MXF）似乎适用于牙源性感染的抗生素治疗。渗透到相关组织中是临床疗效的另一个先决条件。因此，在Wistar大鼠动物模型中测定了血浆、软组织和下颌骨中的MXF水平。
分析了49只大鼠的样本。将组织样本匀浆并沉淀蛋白质。基于非房室分析进行药代动力学评估。
与血浆相比，组织的浓度-时间曲线呈现出更平缓的形状。计算得出的组织：血浆AUC（曲线下面积）比值为：咬肌：血浆 = 2.64，下颌骨：血浆 = 1.13。
在颌面部手术期间和/或术后，抗生素给药被认为是治疗的重要组成部分。由于在Wistar大鼠中显示出对骨和肌肉组织的良好渗透性，MXF可能是该适应症临床应用的一个选择。
