Ardila Carlos-M, Bedoya-García Jader-Alexander
Universidad de Antioquia U de A, Medellín, Colombia.
Biomedical Stomatology Research Group, Universidad de Antioquia U de A, Medellín, Colombia.
Int J Dent. 2022 May 21;2022:4334269. doi: 10.1155/2022/4334269. eCollection 2022.
To assess the clinical and microbiological efficacy of systemic quinolones adjunctive to mechanical therapy in periodontitis patients. systematic review of the scientific literature was carried out. The search scheme comprised the Scopus, PubMed/MEDLINE, SCIELO (Scientific Electronic Library Online), and LILACS (Literatura Latinoamericana del Caribe en Ciencias de la Salud) databases, together with the gray literature. MeSH terms and keywords were utilized to explore publications in all idioms. Only randomized clinical trials (RCTs) that met the selection criteria were included.
A total of 4 RCTs were selected. These RCTs found superior clinical and microbiological efficacy of adjunctive systemic moxifloxacin (MOX) and levofloxacin (LV) compared to subgingival debridement plus placebo. Improvements in PD and CAL were 2.4 ± 0.8 mm and 2.7 ± 0.9 mm for LV, and 1.5 ± 0.5 mm and 1.8 ± 0.5 mm for MOX, respectively. After six months of follow-up, adjunctive MOX reduced the presence of to imperceptible levels, while LV markedly reduced this microorganism. Some adverse events were reported in the LV group and none in the MOX group.
Adjunctive MOX and LV improve probing depth and clinical attachment level compared with subgingival debridement alone in patients with periodontitis. The efficacy of these quinolones against was also superior.
评估全身应用喹诺酮类药物辅助机械治疗对牙周炎患者的临床及微生物学疗效。我们对科学文献进行了系统评价。检索方案包括Scopus、PubMed/MEDLINE、SCIELO（科学电子在线图书馆）和LILACS（拉丁美洲加勒比地区卫生科学文献）数据库，以及灰色文献。使用医学主题词和关键词检索所有语言的出版物。仅纳入符合选择标准的随机临床试验（RCT）。
共选择了4项RCT。这些RCT发现，与龈下刮治加安慰剂相比，辅助全身应用莫西沙星（MOX）和左氧氟沙星（LV）具有更好的临床及微生物学疗效。LV组牙周袋深度（PD）和临床附着丧失（CAL）的改善分别为2.4±0.8mm和2.7±0.9mm，MOX组分别为1.5±0.5mm和1.8±0.5mm。随访6个月后，辅助应用MOX可将[某种微生物名称未给出]的存在减少至难以察觉的水平，而LV可显著减少这种微生物。LV组报告了一些不良事件，MOX组未报告任何不良事件。
与单纯龈下刮治相比，辅助应用MOX和LV可改善牙周炎患者的探诊深度和临床附着水平。这些喹诺酮类药物对[某种微生物名称未给出]的疗效也更优。
