Hamdan Ashraf, Thouet Thomas, Kelle Sebastian, Wellnhofer Ernst, Paetsch Ingo, Gebker Rolf, Schnackenburg Bernhard, Fahmy Ahmed S, Osman Nael F, Bornstedt Axel, Fleck Eckart
Department of Internal Medicine/Cardiology, Deutsche Herzzentrum Berlin, Berlin, Germany.
J Magn Reson Imaging. 2009 Apr;29(4):799-808. doi: 10.1002/jmri.21684.
To define the reproducibility of strain-encoded (SENC) magnetic resonance imaging (MRI) for assessment of regional left ventricular myocardial strain and timing of contraction in a 3T MRI system.
The study population consisted of 16 healthy subjects. SENC measurements were performed in three short-axis (SA) slices (apical, mid, and basal) and three long-axis (LA) views (two-, three-, and four-chamber) for assessment of maximal transmural systolic strain and time to peak strain. To assess the interobserver and interstudy reproducibility, analysis of SENC MRI was performed by two independent observers who were blinded to each other's results and four studies were repeated on a different day.
Maximal longitudinal strain was highest at the apex, as was maximal circumferential strain. Peak longitudinal strain occurred earliest at the base, as did peak circumferential strain. Interclass correlation coefficient between observers and repeated studies ranged from 0.92 to 0.98 (P < 0.001 for all).
The present study demonstrates the ability of SENC MRI to define regional left ventricular strain and the time sequence of regional strain. SENC MRI may represent a highly objective method for quantifying regional left ventricular function.
在3T磁共振成像（MRI）系统中，确定应变编码（SENC）磁共振成像用于评估局部左心室心肌应变和收缩时间的可重复性。
研究对象为16名健康受试者。在三个短轴（SA）层面（心尖、中间和基底）和三个长轴（LA）视图（两腔、三腔和四腔）进行SENC测量，以评估最大透壁收缩期应变和应变峰值时间。为评估观察者间和研究间的可重复性，由两名相互不知道对方结果的独立观察者对SENC MRI进行分析，并在不同日期重复进行四项研究。
最大纵向应变在心尖处最高，最大圆周应变也是如此。纵向应变峰值最早出现在基底，圆周应变峰值也是如此。观察者间和重复研究间的组内相关系数范围为0.92至0.98（所有P<0.001）。
本研究证明了SENC MRI定义局部左心室应变和局部应变时间序列的能力。SENC MRI可能是一种高度客观的量化局部左心室功能的方法。
