Korosoglou Grigorios, Youssef Amr A, Bilchick Kenneth C, Ibrahim El-Sayed, Lardo Albert C, Lai Shenghan, Osman Nael F
University of Heidelberg, Department of Cardiology, Heidelberg, Germany.
J Magn Reson Imaging. 2008 May;27(5):1012-8. doi: 10.1002/jmri.21315.
To compare the utility of the real-time technique fast strain-encoded magnetic resonance imaging (fast-SENC) for the quantification of regional myocardial function to conventional tagged magnetic resonance imaging (MRI).
Healthy volunteers (N = 12) and patients with heart failure (N = 7) were examined using tagged MRI and fast-SENC at 3.0T. Circumferential strain was measured using fast-SENC in six endo- and six subepicardial regions in the basal-, mid-, and apical-septum and the basal-, mid-, and apical-lateral wall from the four-chamber view. These measurements were plotted to tagging, in corresponding myocardial segments.
Peak systolic strain (Ecc) and early diastolic strain rate (Ecc/second) acquired by fast-SENC correlated closely to tagged MRI (r = 0.90 for Ecc and r = 0.91 for Ecc/second, P < 0.001 for both). Both fast-SENC and tagging identified differences in regional systolic and diastolic function between normal myocardium and dysfunctional segments in patients with heart failure (for fast-SENC: Ecc = -21.7 +/- 2.7 in healthy volunteers vs. -12.8 +/- 4.2 in hypokinetic vs. 0.6 +/- 3.8 in akinetic/dyskinetic segments, P < 0.001 between all; Ecc/second = 104 +/- 20/second in healthy volunteers vs. 37 +/- 9/second in hypokinetic vs. -16 +/- 15/second in akinetic/dyskinetic segments, P < 0.001 between all). Quantitative analysis was more time-consuming for conventional tagging than for fast-SENC (time-spent of 3.8 +/- 0.7 minutes vs. 9.5 +/- 0.7 minutes per patient, P < 0.001).
Fast-SENC allows the rapid and accurate quantification of regional myocardial function. The information derived from fast-SENC during a single heartbeat seems to be superior or equal to that acquired by conventional tagging during several heart cycles and prolonged breathholds.
比较实时技术快速应变编码磁共振成像（fast-SENC）与传统标记磁共振成像（MRI）在定量评估局部心肌功能方面的效用。
对12名健康志愿者和7名心力衰竭患者在3.0T条件下进行标记MRI和fast-SENC检查。从四腔心视图在基底、中间和心尖间隔以及基底、中间和心尖侧壁的六个心内膜和六个心外膜下区域使用fast-SENC测量圆周应变。将这些测量结果与相应心肌节段的标记结果进行对比。
fast-SENC获得的收缩期峰值应变（Ecc）和舒张早期应变率（Ecc/秒）与标记MRI密切相关（Ecc的r = 0.90，Ecc/秒的r = 0.91，两者P均<0.001）。fast-SENC和标记法均识别出正常心肌与心力衰竭患者功能失调节段之间局部收缩和舒张功能的差异（对于fast-SENC：健康志愿者的Ecc = -21.7±2.7，运动减弱节段为-12.8±4.2，运动不能/运动障碍节段为0.6±3.8，所有组间P<0.001；健康志愿者的Ecc/秒 = 104±20/秒，运动减弱节段为37±9/秒，运动不能/运动障碍节段为-16±15/秒，所有组间P<0.001）。传统标记法的定量分析比fast-SENC更耗时（每位患者花费的时间为9.5±0.7分钟，而传统标记法为3.8±0.7分钟，P<0.001）。
Fast-SENC可快速、准确地定量评估局部心肌功能。在单次心跳期间从fast-SENC获得的信息似乎优于或等同于在多个心动周期和长时间屏气期间通过传统标记法获得的信息。
