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[成人双侧丘脑胶质瘤:一例报告并文献复习]

[Bilateral thalamic glioma in an adult: a case report and review of the literature].

作者信息

Iwami Ken-ichiro, Arima Toru, Ooka Fumiharu, Asai Takumi, Tambara Masao, Takaoka Toru

机构信息

Department of Neurosurgery, Okazaki Municipal Hospital, 3-1 Kouryuuzi Gosyogo, Okzaki-shi, Aichi 444-8553, Japan.

出版信息

No Shinkei Geka. 2009 Mar;37(3):285-90.

Abstract

We report a case of a 36-year-old woman who had a rare bilateral thalamic glioma (BTG). She complained of memory disorder T1-weighted magnetic resonance imaging revealed enlarged bilateral thalami with homogenous isointensity and no contrast enhancement. Histological examination of the biopsy specimen identified diffuse astrocytoma (WHO grade II). BTG is a rare variant of thalamic neoplasms, which can be distinguished clinically and radiologically from other gliomas. In most of the reported cases, the presenting symptoms were cognitive impairment varying from personality changes to frank dementia. Death usually occurs within two years after onset, independently of adjuvant therapy such as radiotherapy and chemotherapy. On neuroimaging, all of the BTG had a similar appearance, with both thalami being symmetrically enlarged. Our patient has been given radiotherapy and concominant and adjuvant temozolomide in Stupp's regimen. At the time of this writing (5 months after the consultation), there are no neurological symptoms, and no changes on neuroimaging.

摘要

我们报告了一例36岁患有罕见双侧丘脑胶质瘤(BTG)的女性病例。她主诉记忆障碍,T1加权磁共振成像显示双侧丘脑增大,信号均匀等密度,无强化。活检标本的组织学检查确定为弥漫性星形细胞瘤(世界卫生组织二级)。BTG是丘脑肿瘤的一种罕见变体,在临床和影像学上可与其他胶质瘤相鉴别。在大多数报道的病例中,主要症状是认知障碍,从人格改变到明显的痴呆不等。通常在发病后两年内死亡,与放疗和化疗等辅助治疗无关。在神经影像学上,所有BTG表现相似,双侧丘脑均对称增大。我们的患者已按照Stupp方案接受了放疗以及同步和辅助替莫唑胺治疗。在撰写本文时(会诊后5个月),没有神经症状,神经影像学也没有变化。

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