Gilbert D B, Patterson T A, Rose S P
Department of Biology, Open University, Milton Keynes, United Kingdom.
Behav Neurosci. 1991 Aug;105(4):553-61. doi: 10.1037//0735-7044.105.4.553.
Although memory formation occurs in a sequence of pharmacologically dissociable stages, many models assume that this sequence is located within a single neuronal ensemble. Three forebrain areas in the young chick-the intermediate medial hyperstriatum ventrale (IMHV), the lobus parolfactorius (LPO), and the paleostriatum augmentatum--have been identified as important structures in mediating learning and memory processes. It has been shown that pretraining lesions placed to the left IMHV produce amnesia for a 1-trial passive avoidance task. Posttraining lesions in the IMHV are not amnestic. The present study demonstrated that bilateral lesions to the LPO are amnestic but only if made subsequent to rather than before training. These results suggest that long-term storage of the memory is dependent on the LPO. Further experiments determined that in the absence of the LPO at training, the right IMHV can act a long-term memory storage site. In the absence of the right IMHV at training, other, as yet undetermined, areas can take up this role.
尽管记忆形成发生在一系列药理学上可分离的阶段，但许多模型假定这一序列位于单个神经元集合内。幼雏的三个前脑区域——中间内侧腹侧上纹状体（IMHV）、嗅觉叶（LPO）和增新纹状体——已被确定为介导学习和记忆过程的重要结构。研究表明，对左侧IMHV进行训练前损伤会导致一次被动回避任务失忆。IMHV的训练后损伤不会导致失忆。本研究表明，双侧LPO损伤会导致失忆，但前提是在训练后而非训练前进行损伤。这些结果表明，记忆的长期存储依赖于LPO。进一步的实验确定，在训练时没有LPO的情况下，右侧IMHV可以充当长期记忆存储位点。在训练时没有右侧IMHV的情况下，其他尚未确定的区域可以承担这一角色。
