Patterson T A, Rose S P
Department of Biology, Open University, Milton Keynes, United Kingdom.
Behav Neurosci. 1992 Jun;106(3):465-70. doi: 10.1037//0735-7044.106.3.465.
Training chicks on a one-trial passive avoidance task results in memory-dependent synaptic remodeling in the intermediate medial hyperstriatum ventrale (IMHV) and lobus parolfactorius (LPO). Because pretraining IMHV lesions are amnestic and posttraining IMHV lesions are not, the functional significance of this remodeling requires explanation. Chicks use various cues to classify and remember objects. If the IMHV were concerned with memory for only one such cue, then posttraining IMHV lesions would not lead to "amnesia" because animals would still avoid the aversive bead using other contextual cues. This hypothesis was tested using a color discrimination task. IMHV lesions, but not LPO lesions, impair color discrimination, suggesting that the IMHV may be involved in classifying and remembering the bitter bead on the basis of color. Thus, even simple associations are stored in the brain in the form of multiple, dispersed representations.
在一次尝试被动回避任务中训练雏鸡，会导致中间内侧腹侧上纹状体（IMHV）和嗅觉旁叶（LPO）出现依赖记忆的突触重塑。由于训练前IMHV损伤会导致遗忘，而训练后IMHV损伤则不会，因此这种重塑的功能意义需要解释。雏鸡使用各种线索对物体进行分类和记忆。如果IMHV仅涉及对一种此类线索的记忆，那么训练后IMHV损伤不会导致“失忆”，因为动物仍会利用其他情境线索避开厌恶的珠子。使用颜色辨别任务对这一假设进行了测试。IMHV损伤而非LPO损伤会损害颜色辨别能力，这表明IMHV可能参与基于颜色对苦味珠子进行分类和记忆。因此，即使是简单的关联也以多种分散表征的形式存储在大脑中。
