Serrano P A, Rodriguez W A, Bennett E L, Rosenzweig M R
University of California at Berkeley, Department of Psychology 94720, USA.
Pharmacol Biochem Behav. 1995 Nov;52(3):547-54. doi: 10.1016/0091-3057(95)00135-j.
The amnesic effects of protein kinase inhibitors (H-7, HA-156, TFP, W-9, and W-13) on memory formation for a one trial peck-avoidance task in chicks were investigated with bilateral and unilateral injections into either the left or the right intermediate medial hyperstriatum ventrale (IMHV) or the left or right lobus parolfactorius (LPO). All five inhibitors injected bilaterally 5 min pretraining into either the IMHV or LPO or unilaterally into the left IMHV produced amnesia. Unilateral injections into the right IMHV did not produce amnesia. Unilateral injections of W-9 or W-13 into the left but not the right LPO produced amnesia, H-7, HA-156, or TFP did not produce amnesia when injected unilaterally into either the left or right LPO. The time of onset of amnesia produced by injecting TFP and W-13 into the LPO occurred 45 min after training, whereas H-7 produced amnesia significantly later (90 min after training). Amnesia induced by TFP, W-13, and H-7 injected into the LPO occurred significantly later than amnesia produced when these agents were injected into the IMHV. Together these data suggest that the IMHV and LPO process memory sequentially using various protein kinase activities.
研究了蛋白激酶抑制剂（H - 7、HA - 156、TFP、W - 9和W - 13）对雏鸡单次啄击回避任务记忆形成的遗忘效应，通过双侧和单侧注射到左或右中间内侧腹侧纹状体（IMHV）或左或右嗅觉叶（LPO）。在训练前5分钟双侧注射到IMHV或LPO，或单侧注射到左IMHV的所有五种抑制剂均产生遗忘。单侧注射到右IMHV未产生遗忘。单侧注射W - 9或W - 13到左而非右LPO产生遗忘，单侧注射到左或右LPO时，H - 7、HA - 156或TFP未产生遗忘。将TFP和W - 13注射到LPO产生遗忘的起效时间在训练后45分钟，而H - 7产生遗忘的时间显著更晚（训练后90分钟）。注射到LPO的TFP、W - 13和H - 7诱导的遗忘比将这些药物注射到IMHV时产生的遗忘显著更晚。这些数据共同表明，IMHV和LPO利用各种蛋白激酶活性依次处理记忆。
