Means L W, Franklin R D, Cliett C E
Exp Aging Res. 1980 Apr;6(2):175-80. doi: 10.1080/03610738008258354.
The performance of Long-Evans hooded rats of two age groups (450 and 75 days) was observed in open field activity, one-way active avoidance, and passive avoidance conditioning. One-half of the subjects in each group were administered 100 mg/kg of piracetam two hours prior to all testing trials. Younger rats required fewer acquisition trials to reach active avoidance criterion and made more active avoidances on 7-day retention tests than did older rats. Thus, younger rats performed better on both acquisition and retention of active and passive avoidance conditioning. Piracetam did not produce significant behavioral changes in any of the groups on any of the tasks. Neither age nor piracetam was shown to affect activity.
观察了两个年龄组（45日龄和75日龄）的长-伊文斯有帽大鼠在旷场活动、单向主动回避和被动回避条件反射中的表现。每组中有一半的实验对象在所有测试试验前两小时给予100毫克/千克的吡拉西坦。与老年大鼠相比，幼年大鼠达到主动回避标准所需的习得试验次数更少，并且在7天的保持测试中做出了更多的主动回避行为。因此，幼年大鼠在主动和被动回避条件反射的习得和保持方面表现更好。吡拉西坦在任何任务中均未使任何组产生显著的行为变化。未发现年龄和吡拉西坦对活动有影响。
