Henry K R, Guess M B, Chole R A
Acta Otolaryngol. 1983 Mar-Apr;95(3-4):323-7. doi: 10.3109/00016488309130949.
Similarities were noted between the nature of inner ear damage produced by loud sounds and by aminoglycoside antibiotics. Since body temperature affects cochlear function and influences the effects of noise on the ear, a similar effect was predicted for the aminoglycoside, kanamycin. By environmentally elevating the body temperatures of preweanling mice to approximately 1 degree C above that of the normal adult, kanamycin ototoxicity was increased (an average 20.4 dB threshold elevation, vs. 9.3 dB for kanamycin injected mice reared at room temperature). Hyperthermia per se had no influence on auditory thresholds. This may be of relevance to humans with fever who are treated with aminoglycoside antibiotics.
人们注意到，高强度声音和氨基糖苷类抗生素对内耳造成的损伤性质存在相似之处。由于体温会影响耳蜗功能，并影响噪声对耳朵的作用，因此预计氨基糖苷类药物卡那霉素也会有类似作用。通过环境调控使断奶前小鼠的体温比正常成年小鼠体温升高约1摄氏度，卡那霉素的耳毒性增加（平均听阈升高20.4分贝，而在室温下饲养并注射卡那霉素的小鼠听阈升高9.3分贝）。热本身对听阈没有影响。这可能与使用氨基糖苷类抗生素治疗的发热患者有关。
