Lujan Brandon J, Rosenfeld Philip J, Gregori Giovanni, Wang Fenghua, Knighton Robert W, Feuer William J, Puliafito Carmen A
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Ophthalmic Surg Lasers Imaging. 2009 Mar-Apr;40(2):96-101. doi: 10.3928/15428877-20090301-16.
To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF).
Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared.
GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area.
SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.
比较使用频域光学相干断层扫描（SD - OCT）获得的地图样萎缩（GA）图像与使用眼底自发荧光（FAF）获得的图像。
对5例干性年龄相关性黄斑变性患者的眼睛进行SD - OCT和FAF成像，并比较GA的大小和形状。
与视网膜色素上皮完整的周围区域相比，由于脉络膜反射率增加，GA在SD - OCT上显得明亮。SD - OCT和FAF均可重复性地识别GA，两种方法对GA面积的测量具有可比性，平均差异为总面积的2.7%。
SD - OCT可识别并定量GA区域。这些区域的大小和形状与自发荧光图像上的GA区域相关性良好；然而，SD - OCT成像还提供了重要的横断面解剖信息。
