Shukla Dhananjay, Behera Umesh Chandra, Chakraborty Somnath, Mahalakshmi Rajendran, Prasad Noela Marie
Retina-Vitreous Service, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.
Ophthalmic Surg Lasers Imaging. 2009 Mar-Apr;40(2):115-9. doi: 10.3928/15428877-20090301-20.
To evaluate serous macular detachment as a predictor for response of macular edema to intravitreal triamcinolone acetonide.
Sixteen eyes (16 patients) with macular edema and serous macular detachment secondary to diabetic retinopathy (n = 11) or branch vein occlusion (n = 5) were prospectively enrolled. After intravitreal triamcinolone acetonide injection (4 mg/0.1 mL), they were reevaluated at 1 week and 1 and 3 months. The main outcome measure was change in central macular thickness.
The mean baseline central macular thickness was 651.13 +/- 245.96 microm. One month after intravitreal triamcinolone acetonide injection, central macular thickness decreased to 255.38 +/- 80.64 microm (P < .0001). After 3 months, central macular thickness increased marginally to 329.69 +/- 161.98 microm, still significantly less than baseline (P < .0001). There was a significant correlation between the height of serous macular detachment and reduction in central macular thickness at 1 (r = .827) and 3 (r = .835) months (P< .0001).
When serous macular detachment coexists with vascular or microvascular macular edema, it responds to intravitreal triamcinolone acetonide in direct proportion to the height of the serous macular detachment. However, the response begins to fade by 3 months.
评估浆液性黄斑脱离作为黄斑水肿对玻璃体内注射曲安奈德反应的预测指标。
前瞻性纳入16只眼（16例患者），这些患者患有糖尿病性视网膜病变继发的黄斑水肿和浆液性黄斑脱离（n = 11）或分支静脉阻塞继发的黄斑水肿和浆液性黄斑脱离（n = 5）。玻璃体内注射曲安奈德（4 mg/0.1 mL）后，在1周、1个月和3个月时对患者进行重新评估。主要观察指标为中心黄斑厚度的变化。
中心黄斑厚度的平均基线值为651.13±245.96微米。玻璃体内注射曲安奈德1个月后，中心黄斑厚度降至255.38±80.64微米（P <.0001）。3个月后，中心黄斑厚度略有增加，至329.69±161.98微米，但仍显著低于基线水平（P <.0001）。浆液性黄斑脱离的高度与1个月（r =.827）和3个月（r =.835）时中心黄斑厚度的降低之间存在显著相关性（P<.0001）。
当浆液性黄斑脱离与血管性或微血管性黄斑水肿并存时，其对玻璃体内注射曲安奈德的反应与浆液性黄斑脱离的高度成正比。然而，3个月后反应开始减弱。
