Sayar Dror, Mazilis Alex, Kassem Eias, Klein Adi
Department of Pediatrics, Hillel Yaffe Medical Center, Hadera, Israel affiliated to the Rappaport Faculty of Medicine, Technion-Israel Technology Institution
Harefuah. 2009 Jan;148(1):14-6, 89.
Toxocariasis is one of the causes of eosinophilia in peripheral blood and provokes eosinophilic infiltration in internal organs. In Israel, the number of cases of toxocariasis is very low, 3 cases annually, according to the records at the Ministry of Health. Many cases of eosinophilia might be misdiagnosed as hypereosinophilia syndrome (HES), if serological testing for Toxocara is not conducted, leading to inappropriate treatment. The test is for specific serum IgG antibody of Toxocara canis antigen measured by enzyme-linked immunosorbent assay (ELISA). The authors present a 4 year old girl with hypereosinophilia of 40,000 cell/microl, without involvement of target organs. The authors found that toxocara was the cause of hypereosinophilia. After appropriate treatment the number of eosinophils decreases, presenting a measurement of the parasite activity.
弓蛔虫病是外周血嗜酸性粒细胞增多的病因之一，并可引发内脏器官的嗜酸性粒细胞浸润。在以色列，据卫生部记录，弓蛔虫病病例数非常少，每年3例。如果不进行弓蛔虫的血清学检测，许多嗜酸性粒细胞增多病例可能会被误诊为高嗜酸性粒细胞综合征（HES），从而导致不恰当的治疗。该检测是通过酶联免疫吸附测定（ELISA）测量犬弓蛔虫抗原的特异性血清IgG抗体。作者报告了一名4岁女童，其嗜酸性粒细胞增多至40,000个/微升，且未累及靶器官。作者发现弓蛔虫是嗜酸性粒细胞增多的病因。经过适当治疗后，嗜酸性粒细胞数量减少，这体现了寄生虫活性的一种衡量指标。
