Bart Jacob, Kolkman Ard J, Oosthoek-de Vries Anna Jo, Koch Kaspar, Nieuwland Pieter J, Janssen Hans J W G, van Bentum Jan P J M, Ampt Kirsten A M, Rutjes Floris P J T, Wijmenga Sybren S, Gardeniers Han J G E, Kentgens Arno P M
Mesa+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.
J Am Chem Soc. 2009 Apr 15;131(14):5014-5. doi: 10.1021/ja900389x.
A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.
展示了一种基于新型带状线检测器芯片的微流控高分辨率核磁共振流动探头。该工具对于原位监测微反应器中进行的反应非常重要。例如，监测了苄醇与乙酰氯的乙酰化反应。由于具有无损（亚赫兹）分辨率，该探头在代谢组学研究中具有很大的潜力，对600纳升人类脑脊液的分析就证明了这一点。
