Madej Arleta, Koszelewski Dominik, Paprocki Daniel, Brodzka Anna, Ostaszewski Ryszard
Institute of Organic Chemistry, Polish Academy of Sciences Kasprzaka 44/52 01-224 Warsaw Poland
RSC Adv. 2018 Aug 8;8(50):28405-28413. doi: 10.1039/c8ra04583f. eCollection 2018 Aug 7.
A simply and green synthetic protocol based on the selective laccase-oxidation of alcohol to a corresponding aldehyde and a following Ugi reaction in a micellar system made of SDS was developed and is reported herein. Special emphasis was placed on the metal-free chemoenzymatic tandem reaction based on alcohol oxidation strategies using molecular oxygen from air, followed by an Ugi reaction. The reaction was carried out without the use of a transition metal or organic solvents as a reaction medium. The presented protocol offers an efficient and environmentally friendly procedure.
本文报道了一种简单且绿色的合成方法，该方法基于在由十二烷基硫酸钠（SDS）制成的胶束体系中，通过漆酶将醇选择性氧化为相应的醛，随后进行Ugi反应。特别强调了基于使用空气中的分子氧的醇氧化策略的无金属化学酶串联反应，随后是Ugi反应。该反应在不使用过渡金属或有机溶剂作为反应介质的情况下进行。所提出的方法提供了一种高效且环境友好的程序。
