Herbstman Julie B, Mall Jennifer K
Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Columbia Mailman School of Public Health, 722 W168th Street, Room 1217, New York, NY 10032.
School of Medicine, Faculty of Health Sciences, Trinity College Dublin, College Green, Dublin 2.
Curr Environ Health Rep. 2014 Jun 1;1(2):101-112. doi: 10.1007/s40572-014-0010-3.
Exposure to polybrominated diphenyl ethers (PBDE) during sensitive developmental windows can interfere with cognitive function and behavior, which are critical components of neurodevelopment. The association between developmental exposure to PBDEs and neurodevelopment has been extensively studied using animal models. In this review, we focus on the accumulating evidence in humans. Despite methodological, geographical, and temporal differences between studies, the majority of the epidemiologic evidence supports that early life exposure to PBDEs measured during pregnancy and/or during childhood is detrimental to child neurodevelopment in domains related to child behavior, cognition, and motor skills. While the precise mechanism of action of PBDEs on neurodevelopment is unknown, PBDE-induced neurotoxicity via thyroid hormone disruption and direct action of PBDEs on the developing brain have been proposed and tested. Additional studies are suggested to better understand how early life and/or childhood PBDE exposures, including exposure to specific PBDE congeners, impact neurodevelopmental indices.
在敏感的发育窗口期接触多溴二苯醚（PBDE）会干扰认知功能和行为，而认知功能和行为是神经发育的关键组成部分。利用动物模型已对发育过程中接触PBDE与神经发育之间的关联进行了广泛研究。在本综述中，我们关注人类方面不断积累的证据。尽管各研究在方法、地理和时间上存在差异，但大多数流行病学证据支持，孕期和/或儿童期测得的早年接触PBDE对儿童在与行为、认知和运动技能相关领域的神经发育有害。虽然PBDE对神经发育的确切作用机制尚不清楚，但已提出并验证了PBDE通过干扰甲状腺激素以及PBDE对发育中大脑的直接作用而导致神经毒性的观点。建议开展更多研究，以更好地了解早年和/或儿童期接触PBDE，包括接触特定的PBDE同系物，如何影响神经发育指标。
