Department of Obstetrics and Gynaecology, PGIMS, Rohtak, Haryana, India.
Arch Gynecol Obstet. 2009 Dec;280(6):981-5. doi: 10.1007/s00404-009-1042-z. Epub 2009 Mar 26.
The role of genital mycoplasmas, particularly Ureaplasma urealyticum, in the etiology of infertility has been very controversial. An attempt has been made to explore the role of mycoplasma in unexplained infertility.
The study was conducted on 100 women, divided into two groups: 50 cases with unexplained infertility (study group) and 50 cases with confirmed fertility (control group). Three cervical swabs were collected from each case and sent for bacteriological examination for mycoplasmas. Statistical analysis was performed with chi-square test.
Mycoplasmas were isolated from 19 cases (38%) in study group and six cases (12%) in the control group. Out of these, 16 cases (32%) and 4 cases (8%) in the study and control group respectively were positive for U. urealyticum and the difference was statistically highly significant (P < 0.02). Mycoplasma hominis was found to be positive in three cases (6%) and two cases (4%) in the study and control group respectively and was statistically insignificant (P > 0.05). The colonization of mycoplasmas was maximum in the age group 26-30 years and low socio economic group.
U. urealyticum can be considered as an etiological agent in unexplained infertility. It is suggested that culture for U. urealyticum should be carried out in patients with unexplained infertility.
生殖支原体（尤其是解脲支原体）在不孕病因学中的作用一直存在很大争议。本研究旨在探讨支原体在不明原因不孕中的作用。
对 100 例女性进行研究，分为两组：50 例不明原因不孕患者（研究组）和 50 例已确诊妊娠患者（对照组）。从每位患者采集 3 份宫颈拭子，进行支原体细菌学检查。采用卡方检验进行统计学分析。
研究组 19 例（38%）和对照组 6 例（12%）分离出支原体。其中，研究组 16 例（32%）和对照组 4 例（8%）解脲支原体阳性，差异具有统计学意义（P < 0.02）。研究组和对照组人型支原体阳性分别为 3 例（6%）和 2 例（4%），差异无统计学意义（P > 0.05）。支原体定植最多见于 26-30 岁年龄组和低社会经济组。
解脲支原体可视为不明原因不孕的病因之一。建议对不明原因不孕患者进行解脲支原体培养。
