Burns Alistair, Allen Harry, Tomenson Barbara, Duignan Debbie, Byrne Jane
Old Age Psychiatry, University of Manchester, Manchester, UK.
Int Psychogeriatr. 2009 Aug;21(4):711-21. doi: 10.1017/S1041610209008886. Epub 2009 Mar 27.
Agitation is common in people with dementia, is distressing to patients and stressful to their carers. Drugs used to treat the condition have the potential to cause particularly severe side effects in older people with dementia and have been associated with an increased death rate. Alternatives to drug treatment for agitation should be sought. The study aimed to assess the effects of bright light therapy on agitation and sleep in people with dementia.
A single center randomized controlled trial of bright light therapy versus standard light was carried out. The study was completed prior to the mandatory registration of randomized controls on the clinical trials registry database and, owing to delays in writing up, retrospective registration was not completed.
There was limited evidence of reduction in agitation in people on active treatment, sleep was improved and a suggestion of greater efficacy in the winter months.
Bright light therapy is a potential alternative to drug treatment in people with dementia who are agitated.
激越在痴呆患者中很常见,这令患者痛苦,也给其照料者带来压力。用于治疗该病症的药物有可能在老年痴呆患者中引发特别严重的副作用,且与死亡率上升有关。应寻求药物治疗激越的替代方法。本研究旨在评估明亮光疗法对痴呆患者激越和睡眠的影响。
开展了一项关于明亮光疗法与标准光疗法的单中心随机对照试验。该研究在临床试验注册数据库强制要求注册随机对照试验之前就已完成,并且由于撰写报告的延迟,回顾性注册未完成。
接受积极治疗的患者激越减轻的证据有限,睡眠得到改善,且有迹象表明在冬季月份疗效更佳。
对于有激越症状的痴呆患者,明亮光疗法是药物治疗的一种潜在替代方法。