Centre for Natural Products and Drug Discovery, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Molecules. 2011 Apr 13;16(4):3119-27. doi: 10.3390/molecules16043119.
A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids--N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine--were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete ¹³C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
从山鸡椒（Lauraceae）的茎皮中分离得到一种新的双苄基异喹啉，山鸡椒碱（1），以及另外七种已知生物碱——N-丙烯基劳洛替宁（2）、荷叶碱（3）、actinodaphnine、去甲乌药碱、延胡索碱、藜芦定碱和波多宁。除了山鸡椒碱之外，还报道了 N-丙烯基劳洛替宁（2）的完整的 ¹³C-NMR 数据。通过高场 1D 和 2D-NMR、IR、UV 和 LCMS-IT-TOF 光谱数据阐明了生物碱的结构。N-丙烯基劳洛替宁（2）对离体大鼠主动脉显示出适度的血管舒张活性。
