从山鸡椒的树皮中分离得到一种新的双苄基异喹啉类化合物：山鸡椒碱。
Lancifoliaine, a new bisbenzylisoquinoline from the bark of Litsea lancifolia.
机构信息
Centre for Natural Products and Drug Discovery, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Molecules. 2011 Apr 13;16(4):3119-27. doi: 10.3390/molecules16043119.
A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids--N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine--were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete ¹³C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
从山鸡椒（Lauraceae）的茎皮中分离得到一种新的双苄基异喹啉，山鸡椒碱（1），以及另外七种已知生物碱——N-丙烯基劳洛替宁（2）、荷叶碱（3）、actinodaphnine、去甲乌药碱、延胡索碱、藜芦定碱和波多宁。除了山鸡椒碱之外，还报道了 N-丙烯基劳洛替宁（2）的完整的 ¹³C-NMR 数据。通过高场 1D 和 2D-NMR、IR、UV 和 LCMS-IT-TOF 光谱数据阐明了生物碱的结构。N-丙烯基劳洛替宁（2）对离体大鼠主动脉显示出适度的血管舒张活性。
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