Chen Di, Dou Q Ping
The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA.
Int J Mol Sci. 2008 Jun;9(7):1196-1206. doi: 10.3390/ijms9071196. Epub 2008 Jul 12.
Many plant-derived, dietary polyphenols have been studied for their chemopreventive and chemotherapeutic properties against human cancers, including green tea polyphenols, genistein (found in soy), apigenin (celery, parsley), luteolin (broccoli), quercetin (onions), kaempferol (broccoli, grapefruits), curcumin (turmeric), etc. The more we understand their involved molecular mechanisms and cellular targets, the better we could utilize these "natural gifts" for the prevention and treatment of human cancer. Furthermore, better understanding of their structure-activity relationships will guide synthesis of analog compounds with improved bio-availability, stability, potency and specificity. This review focuses on green tea polyphenols and seeks to summarize several reported biological effects of tea polyphenols in human cancer systems, highlight the molecular targets and pathways identified, and discuss the role of tea polyphenols in the prevention and treatment of human cancer. The review also briefly describes several other dietary polyphenols and their biological effects on cancer prevention and chemotherapy.
许多植物来源的膳食多酚因其对人类癌症的化学预防和化疗特性而受到研究,包括绿茶多酚、染料木黄酮(存在于大豆中)、芹菜素(芹菜、欧芹)、木犀草素(西兰花)、槲皮素(洋葱)、山奈酚(西兰花、葡萄柚)、姜黄素(姜黄)等。我们对其涉及的分子机制和细胞靶点了解得越多,就越能更好地利用这些“天然馈赠”来预防和治疗人类癌症。此外,对其构效关系的更好理解将指导合成具有改善的生物利用度、稳定性、效力和特异性的类似化合物。本综述聚焦于绿茶多酚,并试图总结茶多酚在人类癌症系统中已报道的几种生物学效应,突出已确定的分子靶点和途径,并讨论茶多酚在人类癌症预防和治疗中的作用。该综述还简要描述了其他几种膳食多酚及其对癌症预防和化疗的生物学效应。