Kanwar Jyoti, Taskeen Mujtaba, Mohammad Imthiyaz, Huo Congde, Chan Tak Hang, Dou Qing Ping
The Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, and Department of Oncology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA.
Front Biosci (Elite Ed). 2012 Jan 1;4(1):111-31. doi: 10.2741/363.
Over the past decade many scientific and medical studies have focused on green tea for its long-purported health benefits. There is convincing evidence that tea is a cup of life. It has multiple preventive and therapeutic effects. This review thus focuses on the recent advances of tea polyphenols and their applications in the prevention and treatment of human cancers. Of the various polyphenols in tea, (-)-Epigallocatechin-3-gallate (EGCG) is the most abundant, and active compound studied in tea research. EGCG inhibits several molecular targets to inhibit cancer initiation and modulates several essential survival pathways to block cancer progression. Herein, we describe the various mechanisms of action of EGCG and also discuss previous and current ongoing clinical trials of EGCG and green tea polyphenols in different cancer types.
在过去十年中，许多科学和医学研究都聚焦于绿茶，因其长期以来被认为具有有益健康的功效。有令人信服的证据表明，茶是一杯生命之饮。它具有多种预防和治疗作用。因此，本综述重点关注茶多酚的最新进展及其在人类癌症预防和治疗中的应用。在茶的各种多酚中，(-)-表没食子儿茶素-3-没食子酸酯（EGCG）是茶研究中含量最丰富且活性最强的化合物。EGCG抑制多种分子靶点以抑制癌症起始，并调节多种关键的生存途径以阻断癌症进展。在此，我们描述了EGCG的各种作用机制，并讨论了EGCG和绿茶多酚在不同癌症类型中的既往及当前正在进行的临床试验。
