Sharma Pooja, Montes de Oca Mary K, Alkeswani Amena R, McClees Sarah F, Das Tanushree, Elmets Craig A, Afaq Farrukh
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Photodermatol Photoimmunol Photomed. 2018 Jan;34(1):50-59. doi: 10.1111/phpp.12356. Epub 2017 Nov 20.
Skin cancer is the most common type of cancer with increasing incidence rate and public health burden. Solar ultraviolet (UV) radiation causes an array of damaging cellular and molecular events that eventually lead to the development of skin cancer. Despite increased awareness about sun protection, the exposure rate remains high with less than 15% of men and 30% of women using sunscreen on a regular basis. Therefore, there is an imperative need for the development of novel preventive approaches. Skin cancer chemoprevention using phytochemicals either as dietary supplements or by topical applications has gained considerable attention due to their low toxicity, availability, and anticarcinogenic properties. Tea, the second most commonly consumed beverage in the world, is a rich source of promising phytochemicals known as polyphenols. In this review, we discuss the findings of various in vitro, in vivo and human studies signifying the chemopreventive effects of tea polyphenols against UVB-induced skin cancer. This is accomplished by exploring the role of tea polyphenols in DNA repair, inflammation, oxidative stress, signaling pathways, and epigenetics. Finally, this review discusses a variety of innovative delivery methods that enhance the photochemopreventive effects of tea polyphenols against skin cancer.
皮肤癌是最常见的癌症类型，其发病率和公共卫生负担都在不断增加。太阳紫外线（UV）辐射会引发一系列具有破坏性的细胞和分子事件，最终导致皮肤癌的发生。尽管人们对防晒的意识有所提高，但暴露率仍然很高，只有不到15%的男性和30%的女性经常使用防晒霜。因此，迫切需要开发新的预防方法。使用植物化学物质作为膳食补充剂或通过局部应用进行皮肤癌化学预防，因其低毒性、可用性和抗癌特性而受到了广泛关注。茶是世界上第二大最常饮用的饮品，是一种富含被称为多酚的有前景的植物化学物质的来源。在这篇综述中，我们讨论了各种体外、体内和人体研究的结果，这些研究表明茶多酚对紫外线B诱导的皮肤癌具有化学预防作用。这是通过探索茶多酚在DNA修复、炎症、氧化应激、信号通路和表观遗传学中的作用来实现的。最后，这篇综述讨论了多种创新的递送方法，这些方法增强了茶多酚对皮肤癌的光化学预防作用。
